米氮平治疗脑卒中后抑郁的临床观察.pdf

289 2011 年 第 13 卷 第 2 期（总第 88 期） 米氮平治疗脑卒中后抑郁的临床观察 王翌 （河南中医学院一附院艾滋病临床研究中心,郑州 450000） 【摘要】目的:观察米氮平治疗脑卒中后抑郁(PSD)的疗效与安全性。方法:将84例PSD患者随机分成两组。其中研究组42例,应用米氮平 治疗;对照组42例,应用阿米替林治疗;疗程均为6周。采用Hamilton抑郁量表(HAMD)、临床疗效总评病情严重程度量表(CGI-SI)评定临 P 床疗效,副反应量表(TESS)评定药物的不良反应。结果:两组总体疗效相当( ＞0.05),但米氮平起效快,不良反应较轻。结论:米氮平治 疗脑卒中后抑郁疗效显著,不良反应少,安全性高。 【关键词】米氮平; 阿米替林; 脑卒中后抑郁; 临床观察 【中图分类号】 R743 【文献标识码】 A 【文章编号】1009-0959(2011)02-0289-02 Clinical Observation of Mirtazapine Treatment in Patients with Post-stroke Depression Wang Yi (The Henan Traditional Chinese medicine college first affiliated hospital,Zhengzhou 450000, China) ABSTRACT Objective: To investigate the effects and safety of mirtazapine in the treatment of post-stroke depression(PSD). Methods:84 【 】 cases of PSD patient were randomly divided into study (n=42,mirtazapine) and control group (n=42,amitriptyline) for 6 weeks. Clinical curative effects were assessed with the Hamilton Depression Scale(HAMD) and Clinical Global Impression Scale Severity of Illness(CGI- SI) and side effects with the Treatment Emergent Symptom Scale(TESS). Results:There was no significant difference in global curative effect between the two groups(P ＞0.05);mirtazapine took effect quicker, its side effects was milder. Conclusions:Mirtazapine has significant curative efficacy, milder adverse reactions and higher safety in the treatment of post-stroke depression. KEY WORDS Mirtazapine; amitriptyline; Post-stroke depression; Clinical observation 【 】 脑卒中后抑郁