her2 应用.pdfVIP

HER2 Biology, Detection, and Clinical Implications Carolina Gutierrez, MD; Rachel Schiff, PhD N Context.—HER2 is a membrane tyrosine kinase and Data Sources.—Selected literature searchable on PubMed oncogene that is overexpressed and gene amplified in as well as older studies revealed by the literature review about 20% of breast cancers. When activated it provides were reviewed. the cell with potent proliferative and antiapoptosis signals Conclusion.—HER2 is an important member of a and it is the major driver of tumor development and complex signaling network and when gene amplified, it progression for this subset of breast cancer. When shown results in an aggressive subtype of breast cancer. Patients to be overexpressed or amplified by appropriate methods, with tumors found to overexpress HER2 protein or to be HER2 is a valuable treatment target. amplified for the gene are candidates for therapy that Objectives.—To review the basic biology of the HER2 significantly reduces mortality. signaling network, to discuss various approved methods for (Arch Pathol Lab Med. 2011;135:55–62) its detection in clinical specimens, and to describe the impressive results of therapies targeting HER2. uman epidermal growth factor receptor 2 (ERBB2, Remissions sometimes lasting years, although temporary, H formerly HER2/neu, c-erbB2), 1 of a family of 4 are seen in patients with metastatic disease treated with membrane tyrosine kinases (TKs), was found to be ER- and HER2-targeted