组织多肽抗原糖类抗原及癌胚抗原联合检测在大肠癌早期诊断及治疗中的意义.docVIP

组织多肽抗原、糖类抗原及癌胚抗原联合检测在大肠癌早期诊断及治疗中的意义 　　作者：孙玉成,刘在文,李林虎* 作者单位：延边大学附属医院 普通外科,吉林 延吉 133000 　　【摘要】 [目的]探讨组织多肽抗原(TPA)、糖类抗原242(CA242)和癌胚抗原(CEA)3种肿瘤标志物检测在大肠癌诊断和疗效观察中的应用价值.[方法]应用ELISA法测定60例健康成人及82例大肠癌患者血清TPA，CA242和CEA水平，并对34例大肠癌患者行术后随访复检.[结果]大肠癌患者血清TPA，CA242和CEA水平及检测阳性率均明显高于正常组，3项肿瘤标志物联合检测大肠癌的阳性检出率明显升高;大肠癌患者经有效治疗后3项肿瘤标志物水平显著降低.[结论]TPA，CA242和CEA联合检测对大肠癌的诊断及术后疗效观察有意义. 　　【关键词】 肠肿瘤;组织多肽抗原;抗原,肿瘤相关,碳水化合物;癌胚抗原 　　The value of combined detection for tumor markers of TPA，CA242 and CEA in early diagnosis and treatment of colorectal cancer 　　SUN Yucheng， LIU Zaiwen, LI Linhu* 　　(Department of General Surgery, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin, China) 　　ABSTRACT:OBJECTIVETo investigate the applicative value of combined detection for tumor markers of TPA, CA242 and CEA in diagnosis and curative effects of colorectal cancer.METHODSUsing ELISA, the levels of TPA, CA242 and CEA of serum were detected in 60 cases of healthy adults and 82 cases of colorectal cancer, and 34 patients were followed up to detecte again after operation.RESULTSThe levels and positive rates of TPA, CA242 and CEA were more higher in the group of colorectal cancer than in the group of healthy adults, and the levels of 3 kinds of tumor markers in the patients with colorectal cancer decreased obviously after curative treatment.CONCLUSIONThe combined detection for tumor markers of TPA,CA242 and CEA has important significance in early diagnosis, observation of therapeutic effects for colorectal cancer after operation. 　　Key words:intestinal neoplasms;tissue polypeptide antigen;antigens, tumorassociated, carbohydrate;carcinoembryonic antigen 　　大肠癌是消化道常见的恶性肿瘤，发病率呈逐年上升趋势.早期诊断、早期手术及术后综合治疗和行之有效的随访是提高大肠癌治疗效果,改善患者生存质量的重要措施.延边大学附属医院自2003年3月至2007年6月间应用酶联免疫吸附试验(ELISA)法对大肠癌患者进行了血清组织多肽抗原(TPA)、糖类抗原242(CA242)和癌胚抗原(CEA)水平联合检测，共有82例患者接受了完整的3项联合检测及术后随访，其中34例患者于术后3周时进行了完整的3项联合检查的复检. 　　1 材料与方法 　　1.1 研究对象 正常对照组为60名，为健康成年人，年龄为26～60岁，平均为41岁，男女各为30例;大肠癌组为在2003年3月至2007年6月间延边