中药骨筋宝汤对膝关节骨性关节炎患者血清SODNO及MDA水平的影响.docVIP

中药骨筋宝汤对膝关节骨性关节炎患者血清SOD、NO及MDA水平的影响 　　作者：高　志1 ， 邓友章2　 作者单位：(成都中医药大学附属骨科医院(四川省骨科医院)1.膝关节镜科 ;2.骨科 ，四川 成都　610041) 　　【摘要】 目的： 探讨中药骨筋宝汤对膝关节骨性关节炎患者血清超氧化物歧化酶(SOD)、一氧化氮(NO)及丙二醛(MDA)水平的影响，为进一步指导临床治疗提供依据。方法： 60例膝关节骨性关节炎随机分为两组，每组30例，A组常规治疗，B组辅助中药干预组，分别在治疗后的3、6、9 周比较两组血清中SOD、NO及MDA的水平。 结果：与B组比较，A组SOD、NO及MDA水平均明显增高(P0.01); B组SOD各相同时间点数值特别是峰值显著低于A组(P0.01);A组自3周起MDA水平显著升高，至9周维持在较高水平，相同时间点B组各值均明显低于A组 (P0.01)。结论：中药骨筋宝汤可降低自由基损伤因子MDA和NO，升高自由基清除剂SOD水平，促进对膝关节骨性关节炎的治疗作用。 　　【关键词】 中药骨筋宝汤,膝关节骨性关节炎,超氧化物歧化酶(SOD);一氧化氮(NO);丙二醛(MDA) 　　[ABSTRACT] Objective： To explore the influence of Gujing Bao Tang on SOD， NO and MDA levels in patients with osteoarthritis of the knee， in order to provide guidance for further study. Methods：A total of 60 patients with knee osteoarthritis were randomly divided into A group of conventional treatment， B group and Chinese herbs in the intervention group A (30 cases) and group B， which was treated with routine therapy， and TCM treatment group. After treatment of 3w， 6w， 9w， serum SOD， NO and MDA levels of the two groups were detected and compared. Results：SOD， NO and MDA levels of group A were all increased comparing with that of group B (P0.01); SOD levels in group B were all lower than that in group A at the same points， especially the summit value. MDA levels in group A started to increase from week 3， and maintained till week 9， MDA levels in group A were also higher than that in group B at different time points(P0.01) Conclusions： Traditional Chinese medicine Gujing Bao Tang can reduce free radical damage factor MDA and NO， increase levels of free radical scavengers SOD to promote the treatment effects for osteoarthritis of the knee. 　　[KEY WORDS] Chinese medicine Gujing Bao Tang; Knee osteoarthritis， Serum SOD， NO， MDA 　　中医认为膝关节骨性关节炎属于痹证，主要是风、寒、湿之邪，使经络闭阻影响气血运行，导致以肌肉、筋骨、关节发生酸痛、麻木、酸楚或关节肿胀、变形、活动障碍为主要表现的病证。一般认为与组织退化变性和长期磨损有关，早期关节软骨变黄、粗糙、变脆、失去光泽，甚至发灰，继之出现裂纹，软化或剥脱，骨质裸露，以及软骨周围增生，骨赘形成，软骨下骨质致密、硬化、关节肥大、畸形以及发生运动受限，晚期可形成关节积液、畸形、关节内游离体。测定超氧化物歧化酶(SOD)、一氧化