论文三 T细胞疫苗接种抗异种角膜移植排斥的实验研究.pdf

1998 2 23 1 M d J Chin PLA Vol 23 No 1 F b 1998 45 T ¹ 王　晶　陶纪值　 丁　伟º 210002454　 º º 张　力 　王小宁 : W istar T T + + CD4 CD8 T , W istar : T Wistar , , CsA ; ; ; T R779. 65 EXPERIMENTAL STUDY ON T CELL VACCINATION AGAINST XENOCORNEAL TRANS- PLANT REJECTION , , . 454 , 210002 Wang Jin T iao Jizhi Ding W i e t al th Hospital of PLA Nanjing AbstractT h xp rim nts in v itr o on T c ll vaccination against th r j ction of corn a and lymphocyt of x nograft d monstrat d that Guin apig ant ig n could induc th sp cific prolif ration of lymphocyt s of w istar rat. T c ll vaccinat ion could induc anti-idiotypic r spons in vaccinat d mic , w hich involv d both CD+ and CD+ 4 8 subs t s. Sp cific tol ranc to Guin apig tissu ant ig n was achi v d by T c ll vaccination in Wist ar rat. Com- par t iv xp rim nt b tw n T c ll vaccination, CsA and tript olid in v iv o against a x nocorn al graft r j ction show d that T c ll vaccination approximat d to CsA , but w as mor ff ctiv than triptolid in prolonging th sur- vival p riod of x ncorn a in W istar rat. Key wordsT -lymphocyt s; vaccin s; vaccination; corn al transplant ation c/s 8 70, A( CsA) M aRT ( OX-8, CD M cAb ) M aRIL-2R ( ART - , 18) , ,