内科学结缔组织疾病讲稿(国外英文资料).docVIP

内科学结缔组织疾病讲稿 Systemic lupus erythematosus A concept, SLE (systemic lupus erythematosus, SLE) of antinuclear antibodies on a large number of autoantibodies, and its antigen immune reaction, organ and tissue damage caused by an autoimmune disease. Our country is a high development zone. Second, the cause of It has to do with genetics 2. The genetic susceptibility genes is sure: HLA - Ⅲ class C2 live C4 defect; HLA - Ⅱ DR2, DR3 frequency anomaly of a class. Multiple genetic polymorphism is associated with the occurrence of lupus. Overall: SLE is a multigene disease; Multiple genes interact in a certain way to alter normal immune tolerance and cause disease; Related genetic abnormalities were associated with clinical subtypes and their own antibodies; Laboratory animals have protective genes. The environmental factors are sunlight and medicine estrogen 3, pathogenesis and immune abnormalities The foreign antigen stimulates the immune system, produces antibodies, and reacts with the tissue. Pathogenic antibodies 1.1 IgG; 1.2 antiplatelet antibodies and anti-erythroid antibodies; 1.3 anti-ssa (Ro) antibodies; Anti-phospholipid antibody syndrome (thrombosis, thrombocytopenia, habitual spontaneous abortion); 1.5 anti-ribosomal antibodies 2. The pathogenic immune complex immune complex formed by the junction of autoantibodies and their own organization, the deposition in the tissues, activate complement, stimulates the immune damage. T cells and NK cells have dysfunctional CD8 + T cells and NK cells, which continue to be activated. Four, pathology, The main pathological changes of the affected organs are inflammation and vascular abnormalities. The characteristic change: the suki, the nucleus, is turned into an eosinophilic lump; The onion skin lesion, the fibrous tissue around the small artery is hyperplasia. Lupus nephritis and chronic pathologic indicators: Acute indicators Chronic indicators Hyperplastic entity Glomerular sclerosis Cellulose like necrosis/nucleus rupture