丙卡巴肼(PCB、PCZ、甲基苄肼)(国外英文资料).docVIP

丙卡巴肼(PCB、PCZ、甲基苄肼) C kappa hydrazine Chinese generic name: propyl carbazid Generic name: Procarbazine Other names: methylene hydrazine, methylbenzhydrazine, probenzhydrazine, procarbabic, isopropyribenazide Clinical application It is mainly used to treat malignant lymphoma. Also used in malignant melanoma, multiple myeloma, lung cancer and brain tumor. Pharmacology Pharmacodynamics is a derivative of hydrazine, which is a non-specific cell cycle drug. This drug without their own antitumor effect, the red blood cells in the body, and the function of liver microsomal enzymes, generating azo methyl hydrazine benzyl oxide, the latter by the end of the N - methyl transmethylation, methyl transfer to seven of guanine and adenine on one or some of tRNA bases, alkylation specific base, thereby inhibiting the synthesis of DNA, RNA and protein, interfere with the proliferation of tumor cells. There is no cell cycle specificity in this drug, but it mainly blocks the S stage cells from entering G2. In addition, this drug is also a monoamine oxidase inhibitor. 2. Pharmacokinetic this drug oral absorption quickly and completely, blood drug concentration reaches the peak time for 30 to 60 minutes, absorbed rapidly distributed throughout the organization, the highest concentrations in the liver, kidney, easy through the blood brain barrier. Most of them are metabolized in the liver, and the plasma half-life is about 7-10 minutes. It is excreted mainly from urine (about 70% of which is emitted 24 hours, only about 5% of which is the original form of the drug), a small fraction of which is dissolved into carbon dioxide and methane and then expelled through the respiratory tract. Considerations Contraindication (1) the allergy to this drug (foreign information). (2) pregnant women. Use (1) with a bone marrow function. (2) diabetic patients. (3) liver and kidney function not all. (4) accompanied by an infected person. (5) recent patients with radiation or chemotherapy. (6) breastfeedi