细菌群体感应及其在食品变质中的作用.PDF

微生物学通报 JUL 20, 2012, 39(7): 1016−1024 Microbiology China © 2012 by Institute of Microbiology, CAS tongbao@ 专论与综述 细菌群体感应及其在食品变质中的作用 高宗良 谷元兴 赵峰 刘永生* ( 中国农业科学院兰州兽医研究所 家畜疫病病原生物学国家重点实验室 国家口蹄疫参考实验室 甘肃 兰州 730046) 摘 要: 食品相关细菌引起的生物被膜形成和食品变质是食品工业中的重大问题。研究 表明细菌群体感应(Quorum sensing, QS)与被膜形成、食品腐败变质密切相关。重点对细 菌产生的各种 QS 信号分子及其在被膜形成的作用和被膜在食品工业中的重要性做了介 绍。QS 信号分子与食品变质密切相关, 故对 QS 抑制剂作为新型食品防腐剂以延长储存 期限及加强食品安全的前景进行了概述。 关键词: 群体感应, 生物被膜形成, 食品变质 Quorum sensing of bacteria and its effect on food spoilage * GAO Zong-Liang GU Yuan-Xing ZHAO Feng LIU Yong-Sheng (State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory , Lanzhou Veterinary Research Institute , CAAS, Lanzhou, Gansu 730046, China) Abstract: Food spoilage caused by the bacterial biofilm is a significant problems in food in- dustry. It is indicated that quorum sensing of the bacteria plays a major role in biofilm forma- tion and food spoilage. This review focuses on the recent research advances about various quorum-sensing signaling molecules produced by bacteria, the role of signaling molecules in biofilm formation and the significance of biofilms in food industry. As quorum-sensing sig- naling molecules are closely relate to food spoilage, it was also reviewed that quorum-sensing inhibitors can be developed to be used as novel food preservatives for enhance shelf life and food safety. Keywords: Quorum sensing, Biofilm formation, Food spoilage 基金项目：国家自然科学基金项目(No.C1