小柴胡汤抗感染与解热作用的实验研究_钱妍.pdfVIP

·576 · Chin J Nosocomiol Vol.18 No.4 2008 ·　 · 钱　妍, 吴整军 (, 100853) :　。　 , , , 。　(93.3%～26.7%) (P0.05);, , (P0.05)。　, 。 :;; :R378.1　　:A 　　:1005-4529 (2008)04-0576-03 Anti-infection and Anti-pyretic Effect of Minor Dicoction of Bup leurum: An Experimental Study QIAN Yan, W U Zheng-jun (General Hosp ital of PLA , Beij ing 100853, China) Abstract:OBJECTIVE T o obser e the anti-infection and anti-pyretic effect in v ivo of Minor Decoction of Bup leurum (Xiaochaihu T ang ).METHODSThe Strep tococcus p neumoniae infection model in mice and endotoxin- induced fe erish model in rats were prepared, Minor Decoction of B up leurum was used to treat the experimental animals vs Bap hicacanthus cusia Bremek.(Isatis tinctoria)granule in control unimals to obser e death rate of infected animal and the changes in temperature of fe erish animals. ESULTSMinor Decoction of B up leurum had better effect on decreasing death rate of S.p neumoniae infected animal and on low ering the temperature of endotoxin-induced fe erish animal, P0.05.CONCLUSIONS Minor Decoction of Bup leurum has notable effects in anti-infection and anti-pyretic effect in vivo and the mechanism of abatement of fe er is worth further study. Key words:Minor Decoction of Bup leurum;Anti-infection;Anti-pyretic effect 　　,, 1.1.1 　　 45 , 。,, 18 ～22 g, ; SD 30 , ,, 220 ～250 g,,。 。, , (20 ±2)℃,12 h。 [1] 。 1984-2002 1.1.2　　(12 g, [2] 9 g, 9 g, 9 g, 9 g, 6 g, , ,, 9 g ), 。、 ,(、 ,。 )。 1.2　实验方法 、 1.2.1　　 ,, , , 。 55 .16 kPa,