HSV-2gB(1.B.44)sc-57857.PDFVIP

SAN TA C RUZ BI OTEC HNOL OG Y, INC . HSV-2 gB (1.B.44): sc-57857 BACKGROUND APPLICATIONS Membrane fusion is crucial for the entry, spread and formation of enveloped HSV-2 gB (1.B.44) is recommended for detection of glycoprotein B of Herpes viruses, such as herpes simplex virus, and is mediated by envelope glycopro - Simplex Virus 2 origin by Western Blotting (starting dilution 1:200, dilution teins. Two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 range 1:100-1:1000) and immunofluorescence (starting dilution 1:50, dilution or oral) and HSV-2 (type 2 or genital), have been shown to encode at least ten range 1:50-1:500). glycoproteins, four of which are necessary and sufficient to facilitate fusion. Molecular Weight of HSV-2 gB: 113 kDa. These four glycoproteins include glycoprotein B (gB), glycoprotein D (gD), glycoprotein H (gH) and glycoprotein L (gL). The fusion event is dependent SELECT PRODUCT CITATIONS upon the expression of a gD receptor on target cell membranes and does not require the presence of cell-surface glycosaminoglycans. Glycoprotein B is 1. Steukers, L., Weyers, S., Yang, X., Vandekerckhove, A.P., Glorieux, S., essential for viral growth, as gB-free virions are able to bind cells but not to Cornelissen, M., Van den Broeck, W., Temmerman, M. and Nauwynck, H.J. synthesize virus-specific proteins upon infection. HSV-1 and HSV-2 gB exist 2014. Mimicking herpes simplex virus 1 and herpes simplex virus 2 as a homodimer which may be linked by disulfide bonds. HSV-1 gB is a 904 mucosal behavior in a well-characterized human genital organ culture. amino acid protein with an extracellular domain consisting of amino acids J. Infect. Dis. E-published. 31-730 and a cytoplasmic domain consisting of amino acids 796-904