血糖波动幅度与2型糖尿病大血管病变的相关性.docxVIP

 PAGE \* MERGEFORMAT 7 作者单位：710003西安市中心医院内分泌科（成淑英，李楠，张利红，农晰婷） 通讯作者：成淑英E-mail:yanhe_csy@163.com. 血糖波动幅度与2型糖尿病大血管病变的相关性 成淑英 李楠 张利红 农晰婷 [摘要]目的 探讨血糖波动与糖尿病大血管病变严重程度的相关性。方法 选取T2DM患者86例，根据颈内中膜厚度 (carotid intima-thicknessCIMT)将患者分为正常组（A组26例）、颈动脉内中膜增厚组（B组28例）及斑块形成组（C组32例）。所有患者均采用动态血糖监测系统(continuous glucose monitoring system CGMS)监测72 h，计算平均血糖水平(mean blood glucose MBG)、血糖波动最大幅度(Large amplitude of glycemic excursion LAEG)，同时检测糖化血红蛋白(HbAlc)，胆固醇(TG)，甘油三酯(TG)，高密度脂蛋白(HDL-c)，低密度脂蛋白(LDL-c)，结果 (1)单因素方差(One- way?analysis of variance ANOVA)分析比较，3组之间各参数，仅LAGE差异有统计学意义(P0.05)，多重比较发现， LAGE组间均值差有统计学意义 (P0.05);组间均值差分别为A组与B组：-1.29；A组与C组：-5.00，B组与C组：-3.71， 95% confidence interval(CI)分别为（-3.61-1.03；-7.17—2.83；5.80— -1.63）(2)经spearman秩相关分析发现，颈动脉硬化的严重程度与LAGE呈正相关(β=0.573, P0.01)。结论 T2DM患者血糖波动幅度与颈动脉粥样硬化严重程度相关。 [关键词]糖尿病，2型，血糖波动幅度，动态血糖监测系统，颈动脉内中膜厚度 The relationship between blood glucose fluctuations and carotid intima-media thickness (CIMT) in type 2 diabetic patients Chengshuying, Linan,Zhanglihong,et ,al, Department of Endocrinology,The Central Hospital of Xi,an, Xi,an,710004, ShannXi , Province, China. [Abstract]Objective To investigate the relationship between blood glucose fluctuations and carotid intima-media thickness (CIMT) in type 2 diabetic patients. Method:86 patients with type 2 diabetes mellitus (T2DM) in the Department of Endocrinology, The central Hospital of Xi,an were recruited in this study, According to the carotid intima-media thickness (CIMT), the 86 patients with T2DM were divided into three groups:normal CIMT(Agroup:CIMT1.0mm;n=26),CIMT thickening(B group：1.0mm≤CIMT1.5mm n=28) and Carotid plaque(Cgroup:CIMT≥1.5mm n=32)．The glucose excursions were assessed by the following parameters obtained from the continuous glucose monitoring system (CGMS) for 72 h: mean blood glucose (MBG) and its Large amplitude of glycemic excursion LAGE), Glycosylated hemoglobin (HbAlc), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-densit