BIOINFORMATICS DISCOVERY NOTE Sequence analysis.pdfVIP

下载本文档

9
0
约2.76万字
约 5页
2017-04-11 发布于江苏
举报
版权申诉

BIOINFORMATICS DISCOVERY NOTE Sequence analysis.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

BIOINFORMATICS DISCOVERY NOTE Sequence analysis

Vol. 22 no. 23 2006, pages 2841–2845 doi:10.1093/bioinformatics/btl498BIOINFORMATICS DISCOVERY NOTE Sequence analysis Meisetz and the birth of the KRAB motif Zoe? Birtle and Chris P. Ponting Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford, South Parks Road, Oxford OX1 3QX, UK Received on August 8, 2006; revised on September 26, 2006; accepted on September 27, 2006 Advance Access publication October 10, 2006 Associate Editor: Alex Bateman ABSTRACT The largest family of transcription factors in mammals is of Cys2His2 zinc finger-proteins, each with an NH2-terminal KRABmotif. Extensive expansions of this family have occurred in separate mammalian lineages, with 400 such genes known in the human genome. Despite their widespread occurrence, the evolutionary provenance of theKRABmotif is unclear since previously it has not been foundoutside of the tetrapod vertebrates. Here, we show that homologues of the histone methyltransferase Meisetz are present within the sea urchin (Strongylocentrotus purpuratus) genome. Sea urchin and mammalian Meisetz sequences each contain an N-terminal KRAB motif, which thereby establishes an early origin of the KRAB motif prior to the divergence of echinoderm and chordate lineages. Finally, we present evidence that KRAB motifs derive from a novel family of KRI (KRAB Interior) motifs that were present in the last common ancestor of animals, plants and fungi. Contact: chris.ponting@anat.ox.ac.uk Supplementary information: Supplementary data for this article are available at Bioinformatics online. 1 INTRODUCTION Kru?ppel-associated box (KRAB) motif—and kru?ppel Cys2His2 zinc finger-encoding transcription factors present three enduring mys- teries. The first of these is the molecular basis to their unprecedented family expansions in mammalian genomes. KRAB motifs are encoded in either 300–400 genes in the human or mouse genomes (Huntley et al., 2006). Many of these arose either in the human or