Structural bioinformatics Assortative mixing in Protein Contact Networks and protein foldin.pdfVIP

下载本文档

2
0
约4.28万字
约 8页
2017-04-09 发布于江苏
举报
版权申诉

Structural bioinformatics Assortative mixing in Protein Contact Networks and protein foldin.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Structural bioinformatics Assortative mixing in Protein Contact Networks and protein foldin

Vol. 23 no. 14 2007, pages 1760–1767 BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm257 Structural bioinformatics Assortative mixing in Protein Contact Networks and protein folding kinetics Ganesh Bagler and Somdatta Sinha* Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India Received on February 5, 2007; revised on May 8, 2007; accepted on May 8, 2007 Advance Access publication May 22, 2007 Associate Editor: Alfonso Valencia ABSTRACT Motivation: Starting from linear chains of amino acids, the spontaneous folding of proteins into their elaborate 3D structures is one of the remarkable examples of biological self-organization. We investigated native state structures of 30 single-domain, two-state proteins, from complex networks perspective, to understand the role of topological parameters in proteins’ folding kinetics, at two length scales—as ‘Protein Contact Networks (PCNs)’ and their corresponding ‘Long-range Interaction Networks (LINs)’ constructed by ignoring the short-range interactions. Results: Our results show that, both PCNs and LINs exhibit the exceptional topological property of ‘assortative mixing’ that is absent in all other biological and technological networks studied so far. We show that the degree distribution of these contact networks is partly responsible for the observed assortativity. The coefficient of assortativity also shows a positive correlation with the rate of protein folding at both short- and long-contact scale, whereas, the clustering coefficients of only the LINs exhibit a negative correlation. The results indicate that the general topological parameters of these naturally evolved protein networks can effectively represent the structural and functional properties required for fast information transfer among the residues facilitating biochemical/kinetic functions, such as, allostery, stability and the rate of folding. Contact: sinha@ccmb.res.in Supplementary information: Supplementary data are avail