JAK2-STAT3基因多态性对真菌性角膜溃疡患者伏立康.PDFVIP

·临床论著· JAK2-STAT3 基因多态性对真菌性角膜溃疡患者伏立康 唑血药浓度的影响 彭摇 璟1,2,李爽乐2,曾洪波2,邓应平1 作者单位:1(610041)中国四川省成都市,四川大学华西医院眼 科;2(643000)中国四川省自贡市第一人民医院眼科 作者简介:彭璟,毕业于泸州医学院,大学本科,主治医师,研究 方向:眼表疾病、屈光手术。 通讯作者:邓应平,毕业于华西医科大学,博士,教授,硕士研究 生导师,主任医师,研究方向:眼表疾病、屈光手术. dyp558@ 163. com 收稿日期: 2016-08-20 摇 摇 修回日期: 2016-11-08 Effects of JAK2 - STAT3 gene polymorphism on voriconazole plasma concentration in patient with fungal corneal ulcer Jing Peng1,2, Shuang-Le Li2, Hong-Bo Zeng2, Ying- Ping Deng1 1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; 2Department of Ophthalmology, the First People蒺s Hospital, Zigong 643000, Sichuan Province, China Correspondence to: Ying - Ping Deng. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. dyp558@ 163. com Received:2016-08-20摇 摇 Accepted:2016-11-08 Abstract 誗AIM: To investigate the effects of Janus Kinase 2 - Signal Transducers and Activator of Transcription 3 (JAK2 / STAT3) gene polymorphism on the voriconazole plasma concentration in patient with fungal corneal ulcer. 誗METHODS: A total of 56 cases (56 eyes) with fungal corneal ulcer wererecruited in our hospital from March 2012 to February 2015. The concentration of voriconazole plasma in each patient was detected by high performance liquid chromatography with fluorescence detection. Meanwhile, the JAK2 / STAT3 genotype analysis was performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) . 誗 RESULTS: All patients were divided into high voriconazole plasma concentration group ( 35 cases, 62郾 50%) and low voriconazole plasma concentration group (21 cases, 37. 50%) by using standard median as boundary value. There was no significant difference on the male proportion, height, weight, daily dose and adverse reaction of the patients between high and low serum voriconazole concentration group (P 0. 05) . The median trough concentration and the median standardized serum