Bioenergetics.pptVIP

Bioenergetics Oxidation and Reduction Oxidation and Reduction Oxidation of Carbon (1/2) Oxidation of Carbon (2/2) Complete Oxidation of a Hydrocarbon Complete Oxidation of Glucose Oxidizing Agents (e.g., NAD+) Oxidizing Agents (e.g., FAD) Oxidation and Reduction II Reducing Agents (e.g., NADH) Pop Quiz! Energy (another reminder) C H Oxidation Releases Energy Dehydrogenases Dehydrogenases Glyceraldehyde-3-Phosphate Dehydrogenase ATP – Energy Currency of Cells Cellular Respiration, Overview ATP-Producing Pathways Oxidative vs. Substrate-Level Phosphorylation Glycolyis in Detail Glycolyis in Detail Glycolyis in Detail Glycolyis in Detail Glycolyis in Detail Outline of Glycolysis Synopsis of Glycolysis Substrate-Level Phosphorylation Substrate-Level Phosphorylation Bioenergetics Mitochondrial Reactions Pyruvate Oxidation Acetyl CoA Oxaloacetate ? Citrate Krebs Citric Acid Cycle Krebs Citric Acid Cycle Krebs Citric Acid Cycle Bioenergetics Electron Transport Chain Electron Transport Chain Electron Transport Chain Oxidative vs. Substrate-Level Phosphorylation Reverse-Running H+ Pump ATP Bookkeeping ATP Bookkeeping ATP Bookkeeping Anaerobic Respiration Anaerobic Respiration Glycolysis NAD+ Requirement Aerobic NAD+ Regeneration Anaerobic Regeneration Homolactic Acid Fermentation Alcoholic Fermentation Alcoholic Fermentation Mixed-Acid Fermentation (e.g., E. coli) Link to Next Presentation Acknowledgements Glyceraldehyde-3-Phosphate Dehydrogenase That’s a fairly well oxidized carbon… …and there it goes …and there go its electrons… acetyl Coenzyme A What’s this? a.k.a., Citric Acid a.k.a., Tricarboxylic Acid Note that these are per Acetyl-CoA That means two turns of Krebs cycle per Glucose oxaloacetate citrate citric acid Note generation of Proton Motive Force H+ H+ H+ H+ Proton Motive Force glycolysis pyruvate oxidation Krebs cycle electron transport electron transport One glucose yields: 2 ATP in glycolysis 2 NADH in glycolysis 2 NADH as pyruvate enters citric acid cycle 2