考研资料：北京大学细胞生物学第十一章细胞增殖极其调控[下].pptVIP

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考研资料：北京大学细胞生物学第十一章细胞增殖极其调控[下].ppt

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考研资料：北京大学细胞生物学第十一章细胞增殖极其调控[下]

3. Cytokinesis (1) In animal cells (2) In plant cells: The phragmoplast guides cytokinesis in higher plants; The mechanisms cotrolling S-phase initiation in animal cells. The Rb protein acts as a brake in mammalian G1 cells The control of G1 progression and S-phase initiation is often disrupted in cancer cells,leading to unrestrained cell-cycle entry and cell proliferation. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Mitogens stimulate G1-Cdk and G1/S-Cdk activities A simplified model of one way that mitogens stimulate cell division Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. DNA damage checkpoint: Cell-cycle progression is blocked by DNA damage and p53 How DNA damage arrests the cell cycle in G1. Two such checkpoints: 1.One in late G1: provents entry into S phase; 2.One in late G2: provents entry into mitosis; P53: gene regulatory protein.DNA damage activates p53 by an indirect mechanism. Mdm2 acts as a ubiquitin ligase that targets p53 for destruction by proteasomes. Phosphrylated p53 reduce its binding to Mdm2. P21(CKI protein) binds to G1/S-Cdk and S-Cdk and inhibits their activities, thereby helping to block entry into S phase. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. * * The MT of mitotic spindle determine the plane of animal cell division; Mitosis can occur without cytokinesis. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. Contractile ring: Actin and myosinII in the contractile ring generate the force for cytokinesis Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd. The assembly of the cell plate begins in late anaphase and is guided by phragmoplast Evaluation only. Created with Aspose.Slides for