循证医学.ppt.pptVIP

检索的一篇论文  * * 循证医学治疗性疾病案例分析 合作小组成员：郑颖201350528 张晨晨201351101 演讲人：郑颖 2 患者，男性，55岁，二周前因上呼吸道感染服用阿司匹林，近来出现呼吸急促、喘息数小时入院诊断为急性呼吸窘迫综合症。患者入院症状并未加重，医生予以积极治疗不久康复出院。患者事后咨询主治医生，期间连续服用阿司匹林3周对急性呼吸窘迫综合症的治疗是否有辅助作用？ 急性呼吸窘迫综合症男性患者 阿司匹林 安慰剂 有效症状改善 题目：Effect of?Aspirin?on Development of?ARDS?in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. 阿司匹林对急性呼吸窘迫综合症的发展在风险患者的急救部门的LIPS-A 随机临床试验 一、治疗性研究证据真实性评价 Are the results valid? 1. 研究对象是否进行随机化（randomization）分组？ 由论文题目明确说明是随机化临床试验 Randomization and Blinding Eligible participants were centrally randomized in a 1:1 ratio to the aspirin or placebo treatment group using Medidata Balance. Dynamic minimization with a second guess probability of 0.2 was used to randomly allocate treatment assignments while stratifying by center.16?The study participant, clinical team, and all members of the study team were blinded to treatment allocation.合资格参与者集中随机按1:1的比例使用阿司匹林或安慰剂治疗组的Medidata的平衡。随着0.2个猜测概率的动态使用最小化随机分配处理任务的同时对center.16研究参与者，临床团队和研究团队的所有成员都不知道治疗分配。 一、治疗性研究证据真实性评价 Are the results valid? 2. 分配方案是否进行了隐藏？ 论文中说明：参与者集中按照1：1比例使用阿司匹林或安慰剂治疗组的Medidata的平衡。研究参与者，临床团队和研究团队的所有成员都不知道治疗分配。 一、治疗性研究证据真实性评价 Are the results valid? 3. 试验开始时试验组与对照组的基线可比性如何？ Baseline demographics and clinical characteristics, according to treatment allocation, are presented in Table1.??Randomization procedures were effective at equalizing distributions of baseline variables. The median (interquartile range [IQR]) time from hospital presentation to randomization was 7.3 (5.1-10.2) hours. The median age was 57 (45-68) years and 52% (203/390) were male. Baseline lung injury prediction scores (LIPS) were not significantly different between groups, with a median (IQR) LIPS of 6.0 (5.0-7.5) in the aspirin group and 5.5 (4.5-7.0) in the placebo group. Major risk factors for ARDS were similarly distributed in both treatment groups. Table 1.??Demographics and Baseline Characteristics of the 390 Participants Included in the Modified