表阿霉素外渗后局部组织损伤处理的实验研究.docVIP

三种不同疗法对表阿霉素外渗后局部组织损伤处理的效果比较 敬雪明1 李芸2 罗万红1 李逸1 （1 川北医学院附属医院风湿血液科 四川南充 637000） （2 四川大学华西医院 四川成都 610041） 摘要 目的 比较三种不同疗法对表阿霉素外渗后局部组织损伤的效果比较,以寻找合理的处理方法。 方法 制作两种表阿霉素外渗动物模型（模型I为单纯表阿霉素外渗，模型Ⅱ为表阿霉素外渗伴局部组织淤血），分别采用临床常用的3种方法进行动物实验对照性研究，局部损伤组织分别用云南白药加50%乙醇湿敷（A疗法）；50%的硫酸镁湿敷（B疗法）；2%利多卡因加地塞米松对局部损伤组织环形封闭（C疗法）；对照组未给任何治疗者，并进行肉眼和组织学观察。 结果 4组间观察2天损伤组织无显著差异（P0.05），第7天局部组织充血水肿、炎性细胞浸润显著消退，以云南白药加50%乙醇湿敷组为优，50%的硫酸镁湿敷对局部组织充血水肿（模型I）有较好疗效，2%利多卡因加地塞米松环形封闭对表阿霉素外渗伴局部组织淤血的疗效较好，模型Ⅱ的病情、组织修复难度重于或大于模型I。结论 临床处理表阿霉素外渗应根据局部组织损伤的不同特点选择合理有效的方法进行应对性处理。 关键词 血管外渗；表阿霉素；疾病模型；动物 Comparision on effects of 3 treatment methods on Managing Local Tissue Damage Caused by Extravasation of Pharmorubicin Jing Xue-Ming1, LI Yun2, Luo Wan-Hong1, LI Yi1 (1 Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China;) ( 2 West China Hospital, Sichuan University, Chengdu 610041, China) Abstract: Objective Comparision on effects of 3 treatment methods on Managing Local Tissue Damage Caused by Extravasation of Pharmorubicin. Methods Two animal models were established: extravasation of pharmorubucin without other complications in Model I, extravasation of pharmorubucin complicates congestion in local tissue in Model Ⅱ. Three methods were introduced to manage local damages: Yunnan white powder and 50% ethanol hydropathic compress (Therapy A), 50% magnesium sulfate hydropathic compress(Therapy B), 2% lydocaine and hexadecadrol blocking damaged tissue in a ring shape(Therapy C), and a control group received no therapy. Observe and compare local and histological outcomes. Results No significant difference in severity of tissue damage was found among 4 groups after 2 days. Congestion, edema and inflammatory cell infiltration of local tissue were improved significantly after 7 days. Therapy A produces notable effects. Therapy B acquired good effects in managing congestion and edema of local tissue in Modal I. Therapy C achieved satisfactory management