低聚果糖通便作用的研究.docVIP

低聚果糖通便作用的研究 发布: 2005-1-1 | 来源: 互联网 | 查看: 2次 免费点歌 绝色美女 手机铃声 ?小 中 大 | 转发 | 收藏本文 ? ? ???????? 作者:何为涛，赵鹏，刘荣珍，李凤文，姚思宇 【摘要】? 目的? 研究低聚果糖的通便功能作用。方法? 动物实验：分别以2.5、5.0和10.0 g／(ｋｇ·ｂｗ)３个剂量经口给予小鼠连续灌胃，７天后进行小肠运动实验、排便时间、粪便粒数和粪便重量的测定。结果? 各剂量组的墨汁推进率均高于便秘模型对照组，各剂量组的首便时间均比便秘模型对照组的缩短，而各剂量组粪便粒数均多于便秘模型对照组，且差异有显著性；人群试食试验：选择非器质性便秘者102例，分为试食组和对照组各51例，两组试验期间不改变原来的饮食习惯，正常饮食，试食组加服低聚果糖，3次/ｄ，每次10ml。7天后，比较两组试验前后排便次数、排便状况和粪便性状的变化，并测定试验前后血常规、血生化指标等。结果? 试验组服用后排便次数明显增加（p0.01），排便状况和粪便性状明显改善（p0.01），总有效率为92.2％（p0.01），且受试者的血常规、血液生化指标及其他临床检查均无异常。结论? 低聚果糖具有通便功能。? ???? ? ???? 【关键词】? 低聚果糖；通便；人体试验? ???? ? ???? study on the effect of fructooligosaccharide facilitating feces excretion? ?????? ???? 【abstract】? objective? to study the effect of fructooligosaccharide on facilitating feces excretion.methods? in vivo animal experiment： in the experiment， mice were given fructooligosaccharide samples through oral gavage at 2.5，5.0 and 10.0g/(kg·bw) for seven consecutive days. then the rate of indian ink advancing in the small intestines， the time of first black feces excretion，the number of feces granules and the weight of feces were measured.results? we found that the rate of indian ink advancing in the small intestines of mice treated with fructooligosaccharide was significantly higher than that in the constipation control group. also compared to the constipation control mice， the first black feces excretion was significantly faster in the mice treated with fructooligosacharide.? furthermore， mice treated with fructooligosacharide samples produced more feces granules than the control group. in vivo human study： 102 constipation patients were randomly divided into two groups. both the treated group and the control group contained 51 patients. patients maintained their regular diet throughout the experiment. however， patients in the treated group were given 25g/day fructooligosaccharide for seven consecutive days. then， the frequency of feces excretion， ease of feces excretion and the appearance of feces granu