紫荆花红色素对模型动物血糖和血脂的影响研究_王金亭_吴广庆_杨敏一..doc

网络出版时间：2013-03-15 13:34 网络出版地址：/kcms/detail/11.1759.TS1334.019.html 紫荆花红色素对模型动物血糖和血脂的影响研究? 王金亭,吴广庆,杨敏一 （聊城大学东昌学院，山东聊城 252000）  摘  要：目的：观察紫荆花红色素对模型动物血糖和血脂水平的影响。方法：腹腔注射四氧嘧啶制备糖尿病小鼠模型，灌胃  高脂乳剂制备高脂血症大鼠模型。将动物分成对照和高、中、低不同剂量组，按动物体重给药实验。强生血糖仪测定小鼠血 糖浓度，试剂盒法测定血清TC、TG、HDL-C和LDL-C等生化指标。结果：四氧嘧啶致糖尿病小鼠造模成功，紫荆花红色素 各剂量组使小鼠体重显著增大，高、中剂量组使血糖显著降低（p＜0.01）。高脂乳剂致SD大鼠高脂血症造模成功，红色素各 剂量组均使大鼠血清TC和LDL-C水平显著降低，中、高组显著降低TG水平和LDL-C/HDL-C比值（p＜0.05），高剂量组对 HDL-C水平具有明显的调节作用(p＜0.01)。结论：紫荆花红色素对四氧嘧啶致糖尿病小鼠血糖水平和高脂血症大鼠的血脂水 平有显著调节作用。 关键词：紫荆，红色素，模型动物，糖尿病，高脂血症  中图分类号： TS264.4  文献标识码：A  文章编号： Study of red pigment from flowers of Cercis chinensis Bge. on blood glucose and serum lipid levels in model rats WANG Jin-ting, WU Guang-qing，YANG Min-yi ( Liaocheng University Dongchang College ,Liaocheng City,Shandong ,252000 China) Abstract： Objective： To explore the effect of red pigment from flowers of Cercis chinensis Bge. on blood glucose and serum lipid levels in model rats. Method: The diabetes mellitus rat model was induced with alloxan (ALX) by abdominal cavity injecting and hyperlipidemia by intragastric administration of high-fat cream in SD rats. Animals were divided into control group and different doses groups (high, middle and low), and dosed according to body weight of rats. The serum glucose consistence was determined by blood glucose monitor and serum TC, TG, HDL-C and LDL-C were detected by corresponding reagent box. Results： Diabetic model rats were treated with alloxan successfully. Each dose group of red pigment from flowers of Cercis chinensis Bge. can increase body weight and middle dose, high dose all can decrease the blood glucose of diabetic rats markedly (p＜0.01). The hyperlipoidemia model rats were treated with high-fat cream successfully. The red pigment can decrease the serum contents of TC and LDL-C significantly(p＜ 0.05), middle dose and high dose can decrease the levels of TG(p＜0.05) and the value of LDL-C/HDL-C and arteriosclerotic i