HBT AbstrctHBT Abstract.docVIP

HBT Abstract Rev Esp Enferm Dig.?2013 Jan;105(1):13-18. Impact of orocecal transit time on patient′s perception of lactose intolerance. Casellas F,?Aparici A,?Casaus M,?Rodríguez P,?Malagelada JR. Abstract Background: symptoms attributed to the lactose intolerance are an important public health issue because of their prevalence and social relevance. Also because they may cause undue rejection of dairy products consume with potential health consequences. Transit time is a putative factor implied in the severity of symptoms associated with lactose.Objectives: to elucidate the relation between orocecal transit time (OCTT) and lactose intolerance symptoms.Methods: observational study in patients referred to a lactose?hydrogen?breath test?who showed an increase in?breath?H2 excretion higher than 25 ppm. OCTT was measured with the?breath test?and symptoms of lactose tolerance with a validated scale. Symptoms were measured twice: before receiving the lactose, inquiring about self perceived symptoms when patients consumed dairy products at home (home symptoms), and again after completing the lactose?breath test?(test?symptoms).Results: 161 patients were included. There was no correlation between OCTT and home symptoms (r = -0.1). When OCTT was faster than 60 minutes, intensity of test?symptoms was similar to home symptoms. However, in patients with normal or slow OCTT, the home symptoms were more intense than the test?symptoms (p 0.05). At home, symptoms were independent of OCTT but with the lactose?test?load the symptoms were proportionately more intense with faster OCTT.Conclusions: in lactose maldigesters, selfreported symptoms of lactose intolerance are more pronounced at home than after a high lactose challenge. Intolerance symptoms that patients attributed to lactose consume at home are due to factors other than fast OCTT. Methane and?hydrogen?positivity on?breath test?is associated with greater body mass index and body fat. Mathur et al. 98 (4): E698 JCEM Onli