基因组dna甲基化研究述基因组dna甲基化研究综述.docVIP

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基因组dna甲基化研究述基因组dna甲基化研究综述.doc

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基因组dna甲基化研究述基因组dna甲基化研究综述

目录摘要·······························································································································1 Abstract·························································································································1 1 甲基化机制··············································································································3 1.1 动物中DNA甲基化机制··················································································3 1.2 植物中DNA甲基化机制··················································································4 1.3 DNA甲基化与组蛋白甲基化的关系·······························································5 1.4 甲基化DNA抑制基因转录沉默的机制·························································6 2 甲基化研究技术·····································································································7 2.1 甲基化敏感扩增多态性·················································································8 2.2 单分子实时测序法直接检测DNA甲基化·····················································9 2.3 依赖于单分子纳米孔技术的测序·································································9 3 甲基化应用···········································································································10 3.1 DNA甲基化在植物中的应用········································································10 3.2 DNA甲基化在动物中的应用········································································10 4 展望·······················································································································12 参考文献···················································································································13 基因组DNA甲基化研究进展摘要：动植物基因组中存在广泛的DNA甲基化修饰，主要存在于CpG和CpNpG位点。作为表观遗传学最重要的现象之一，DNA甲基化在调控自身基因表达，抵御外来入侵DNA、转座子元件及转基因沉默从而维持基因组稳定等方面具有重要作用。文章主要对甲基化的发生、作用机制，甲基化研究相关技术及甲基化研究应用方面做了简要介绍。关键词：表观遗传；DNA；甲基化；甲基转移酶；组蛋白 Advances of Research on Genomic DNA methylation Pengfei liu (College of Life Science，Guizhou University，G