长期家庭无创正压通气治疗对重度慢性阻塞性肺疾病合并ⅱ型呼吸衰竭患者稳定期的临床效果.docVIP

姓名陈黎仙，1970年12月出生，莆田市第一医院男，汉族，籍贯仙游，大学本科，副主任医师，研究方向慢性阻塞性肺疾病 陈黎仙 莆田市第一医院呼吸内科 福建莆田 351100 【摘 要】目的：长期家庭无创正压通气治疗对重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者稳定期的临床效果。方法：选取2007年12月至2014年5月来我院治疗重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的患者120例为研究对象，根据治疗方法的不同将其分为两组，每组各患者60例，对照组接受常规药物治疗和长期家庭氧疗，研究组在采取上述措施的同时实施无创正压通气治疗，患者出院后随访两年，比较两组临床效果。结果：出院时，两组在肺功能和血气分析情况等均不存在显著差异（P0.05），没有统计学意义；2年后，研究组FEV1评分为（1.12±0.18）分，对照组为（0.76±0.22）分；研究组PO2为（68.54±5.89）mmHg，对照组为（47.07±4.56）mmHg；研究组PaCO2为（42.12±12.13）mmHg，对照组为（64.11±10.14）mmHg，组间差异均较大（P0.05），有统计学意义；研究组使用呼气剂的时候出现人机不协调、面部压迫性损伤、胃肠胀气和口咽干燥等不良反应，经指导后均得到有效改善。结论：在重度慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者稳定期治疗期间，给予患者长期家庭无创正压通气治疗，能够有效缓解患者临床症状。 【关键词】重度慢性阻塞性肺疾病；Ⅱ型呼吸衰竭；无创正压通气；稳定期 Long-term home noninvasive positive pressure ventilation therapy for severe chronic obstructive pulmonary disease with clinical effect of plateau type Ⅱ respiratory failure patients Chen li xian Respiratory medicine the first hospital of the city Fujian putian 351100 【Abstract】Objective: to treat chronic obstructive pulmonary disease complicated with type II respiratory failure in patients with chronic obstructive pulmonary disease by long-term home non-invasive positive pressure ventilation. Methods: in December 2007 to 2014 may come to our hospital treatment of severe patients with chronic obstructive pulmonary disease combined with type II respiratory failure in 120 cases for research object, according to the different treatment methods will be the into two groups,60 cases in each each patient, The control group received conventional drug therapy and long-term home oxygen therapy, the study group to implement noninvasive positive pressure ventilation in the treatment of these measures at the same time, the patient was discharged after two years of follow-up, clinical results were compared. Results: when they were discharged from the hospital, two groups in the lung function and blood gas analysis do not exist significant differences,(P0.05),no statistically significant; Two years later, the study group FEV1 score was (1.12 ± 0.18) poin