孟鲁司特辅助治疗毛细支气管炎35例临床效果观察.docVIP

孟鲁司特辅助治疗毛细支气管炎35例临床效果观察 　　[摘要] 目的 观察孟鲁司特对毛细支气管炎的疗效。 方法 将70例毛细支气管炎患者随机分成对照组（n = 35）和治疗组（n = 35）。两组均常规给予抗生素、全身用激素、局部雾化吸入、吸氧等综合治疗，治疗组同时加用孟鲁司特口服，每晚4 mg，连用4周。分别观察两组的疗效，并随访3个月内两组再发喘息的情况。 结果 治疗组总有效率明显高于对照组（χ2=6.44，P 0.05）；症状缓解及症状消失时间均短于对照组（χ2=2.28、2.38，P 0.05）；且治疗后喘息发作次数低于对照组（χ2=4.48，P 0.05）。 结论 孟鲁司特辅助治疗毛细支气管炎安全有效，且能预防反复喘息发作。 　　[关键词] 毛细支气管炎；孟鲁司特；辅助治疗 　　[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721（2013）06（c）-0075-02 　　Clinical efficacy observation of montelukast on 35 cases of bronchiolitis 　　WANG Shanlin CHU Zhaole 　　Department of Pediatrics，Tongcheng Peoples Hospital of Anhui Province，Tongcheng 231400，China 　　[Abstract] Objective To observe the treatment effects of montelukast on bronchiolitis.Methods Seventy cases of bronchiolitis patients were randomly divided into control group （n = 35） and treatment group （n = 35）.Conventional therapy，such as antibiotics，systemic steroid use， local aerosol inhalation，and oxygen treatment were given to both groups.The treatment group was added with montelukast at the same time，4 mg oral every night，insist on four weeks. The treatment effects of the two groups was observed，and the condition of repetition occur wheezing within three months was followed up.Results The effective rate in the treatment group was higher than that in the control group （χ2=6.44，P 0.05）；symptoms of the treatment group and the disappearance of time was shorter than that of the control group （χ2=2.28，2.38，P 0.05），and the recurrent post-bronchiolitis wheezing with montelukast was less than without montelukast （χ2=4.48，P 0.05）.Conclusion Montelukast as adjuvant treatment of bronchiolitis is safe and can effective，and can reduce repetition occur wheezing. 　　[Key words] Bronchiolitis；Montelukast；Adjuvant treatment 　　毛细支气管炎是儿童比较常见的呼吸道感染性疾病，多发生在2岁以下的小儿，80%在1岁以内，多数是6个月以下的小儿。毛细支气管炎的病原主要为呼吸道合胞病毒，少数病例可由腺病毒、副流感病毒、鼻病毒、流感病毒、肺炎支原体等引起；病毒感染后，可致毛细支气管充血，水肿，黏液分泌增多，引起明显的肺气肿和肺不张。临床表现以喘憋为主，甚至可出现呼吸、循环衰竭而致死，且患过毛细支气管炎的患儿易反复喘息发作，甚至部分可发展为哮喘[1]，目前尚无特效治疗方法。本研究对2012年1月～2013年1月本院诊