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Worldwide incidence of HCC YAP improves cell proliferation YAP induces anchorage-independent growth IHC results of YAP in HCC Clinical association of nuclear YAP and HCC-specific postsurgical recurrence Nuclear YAP is an independent prognostic marker for HCC recurrence Summary YAP confers tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion. YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein (AFP) levels. Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival. YAP plays an important role in HCC development and progression. * The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma 徐 智 南京医科大学附属南京第一医院暨 南京市第一医院 肿瘤内科 Blum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71. Identification of Yes-associated Protein (YAP) Zender, L. et al. Cell 125, 1253-67 E F G H Time (Days) *:p0.05。 MIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar. MIHA-YAP cells gained advantages in cell migration and invasion. YAP enhances cellular mobility and invasiveness 53.7% HCC samples showed nuclear YAP positive. Clinical association of nuclear YAP in HCC Kaplan-Meier Median RFT: Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive:12.9 months Cox Regression Acknowledgement 新加坡国立大学外科系和药学系 Asso. Prof. John M. Luk 香港大学外科系 Prof. Fan S. T.,Prof. Poon R. T. and Surgical Tissue Bank 南京市第一医院肿瘤内科 * * *
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