20151DevBioIntroduction技术总结.ppt

华中师范大学生命科学学院 王玉凤 Developmental Biology发育生物学 Yu-Feng Wang (王玉凤） yfengw@ Tel: 6786-7021 Looking forward to having a wonderful time with all of you.Hope that you all enjoy the class. 课程成绩分布 平时成绩：60% ---作业，三次，共60分 ---课件制作及演讲，1次，20分（以小组进行，每个人都必须参与） ---学习态度（平时回答问题及参与活动的积极性、考勤等)，20分 期末考试：40% Introduction 1. What is developmental biology? 2. Where the subject came from? 3. The major model organisms 4. Techniques for the study of development 5. Why study Development? It discusses: Gametogenesis（配子发生） Fertilization Early development Differentiation of germ layers (Cell differentiation and embryonic induction) Some classical or hot topics: Sex determination Nuclear “totipentency（全能性）” and “plasticity（可塑性）” Developmental anomaly Obesity and disease Aging and death Development and evolution References (books): Scott F. Gilbert, 2013. Developmental Biology (Tenth ed.) Sinauer Associates Sunderland Twyman RM，2002. Instant Notes in Developmental Biology（影印版）. 科学出版社 Lewis Wolpert et al., 2002. Principles of Development Oxford University Press Jonathan Slack 2002 Essential Developmental Biology（影印版）. 高等教育出版社 王玉凤主编 2011 发育生物学 科学出版社 张红卫主编 2006 发育生物学（第二版） 高等教育出版社 桂建芳，易梅生主编 2002 发育生物学 科学出版社 Websites Developmental Biology Online / / …… 2. History of “Developmental Biology” (1) Ancient Greece (2) Theory of preformation （预成论）： the early embryo comprises a miniature（微小体） of the adult, and development consists entirely of growth. (3) Theory of epigenesis： The organs of the embryo are formed de novo at each generation. （ supported by Aristotle and Wolff：1738－1794） “Von Baer’s laws”: (4) Theory of Cell (Schleiden and Schwann) : All the organisms are composed of cells, which can only produce by cleavage（分裂） from other cells. So, the life couldn’t be preformed, it must be created de novo each generation. (5) At the beginning of twenty centuries Brothers Hertwig （1849－1922；1850－1937）attracted scientists to nuclei and stated that