神经肽Y对大脑皮质神经元保护.docVIP

神经肽Y对大脑皮质神经元的保护 神经肽Y具有保护神经元的作用，但其是否通过调节小胶质细胞的免疫活性和减少细胞因子等途径尚不明晰？中国河北医科大学赵文清教授所带领的团队研究证实，神经肽Y可以降低过度激活的小胶质细胞免疫活性，避免过量生成白细胞介素1β和肿瘤坏死因子α，降低了大鼠大脑皮质神经元N-甲基-D-天冬氨酸电流密度，从而抑制皮质神经元过度兴奋，起到保护神经元的作用。相关文献发表于《中国神经再生研究（英文版）》杂志2014年5月第9期。 免疫组化染色结果显示，原代培养的神经元具有轴突和长的树突，并表达微管相关蛋白2（箭头） Article: Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function, by Qijun Li1, Changzheng Dong2, Wenling Li2, Wei Bu3, Jiang Wu2, Wenqing Zhao1, 2 (1 Graduate School, Hebei Medical University, Shijiazhuang, Hebei Province, China; 2 Department of Functional Neurosurgery, Hebei General Hospital, Shijiazhuang, Hebei Province, China; 3 Department of Neurosurgery, Third Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China) Li QJ, Dong CZ, Li WL, Bu W, Wu J, Zhao WQ. Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function. Neural Regen Res. 2014;9(9):959-967. 欲获更多资讯： Neural Regen Res Neuropeptide Y protects cerebral cortical neurons Neuropeptide Y exhibits neuroprotective effects. Whether the neuroprotective effects are mediated by the pathways including regulating the immunological activity of reactive microglia and reducing cytokines remains unclear. Prof. Wenqing Zhao, Graduate School, Heibei Medical University, China and his team confirmed that neuropeptide Y prevented excessive production of interleukin-1β and tumor necrosis factor-α by inhibiting microglial reactivity, reduced N-methyl-D-aspartate current in rat cortical neurons, preventing excitotoxicity, and thereby protecting neurons. Related results were published in Neural Regeneration Research (Vol. 9, No. 9, 2014). Immunohistochemical staining reveals that primary cultured neurons extended axons and long dendrites and expressed microtubule-associated protein 2 (arrow). Article: Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function, by Qijun Li1, Changzheng Dong2, Wenling Li2, Wei Bu3, Jiang Wu2, Wenqing Zhao1, 2 (1 Gra