FPGA-based Monte Carlo Computation of Light Absorption for.pdfVIP

FPGA-based Monte Carlo Computation of Light Absorption for Photodynamic Cancer Therapy 1 1 2 1 2 1 Jason Luu , Keith Redmond , William Chun Yip Lo , Paul Chow , Lothar Lilge , Jonathan Rose 1The Edward S. Rogers Sr. Department of Electrical and Computer Engineering 2Department of Medical Biophysics, Ontario Cancer Institute University of Toronto, Toronto, Ontario, Canada Abstract—Photodynamic therapy (PDT) is a method of treating cancer that combines light and light-sensitive drugs to selectively destroy cancerous tumours without harming the healthy tissue. The success of PDT depends on the accurate computation of light dose distribution. Monte Carlo (MC) simulations can provide an accurate solution for light dose distribution, but have high computation time that prevents them from being used in treatment planning. To alleviate this problem, a hardware design of an MC simulation based on the gold standard software in biophotonics was implemented on a large modern FPGA [1]. This implementation achieved a 28-fold speedup and 716-fold lower power-delay product compared to the gold standard software executed on a 3 GHz Fig. 1. Photon propagation in a realistic, five-layer skin model using an Intel Xeon 5160 processor. The accuracy of the hardware was infinitely narrow beam at 633nm compared to the gold standard using a realistic skin model. An experiment using 100 million photon packets yielded a light dose distribution that diverged by less than 0.1 mm. We photon packets within the tissue layers f