Grindstonechemistryahighlyefficientandgreenmethod.PDFVIP

RSC Advances PAPER Grindstone chemistry: a highly efficient and green method for synthesis of 3,4-dihydropyrimidin-2- Cite this: RSC Adv., 2014, 4, 35559 (1H)-ones by L-tyrosine as an organocatalyst: a combined experimental and DFT study† Anamika Khaskel,a Prasanta Gogoi,a Pranjit Barman*a and Biman Bandyopadhyayb A single step, mild, environmentally friendly green method has been developed for the synthesis of physiologically active 3,4-dihydropyrimidin-2-(1H)-ones employing L-tyrosine as catalyst under solvent- Received 11th June 2014 free conditions at room temperature via grinding. The procedure is efficient, time saving and gives high- Accepted 6th August 2014 yields. The structures and purity of these compounds were confirmed by FT-IR, NMR (1H and 13C) and DOI: 10.1039/c4ra05244g HRMS spectral analysis. DFT calculations have been used to show the effectiveness of L-tyrosine as a /advances suitable catalyst for the above reaction. Introduction 3,4-Dihydropyrimidines are well-known for their wide range of bioactivities and their applications in the eld of drug Development of less hazardous synthetic methodologies for research.3–6 3,4-Dihydropyrimidin-2-(1H)-ones (DHPMs) have organic reactions is one of the most sought aer problems in high pharmacological value and they are used as calci