6-monthresults-StrokeOxygenStudy.pptVIP

Background Oxygen saturation within the first 72 hours of acute stroke Adverse effects of hypoxia after stroke IEarly deterioration  Adverse effects of hypoxia after stroke II Increased mortality N=153 assessed from arrival and during transfers till ward admission Hypoxia defined as SpO290 for 10% of assessment phase Oxygen saturation lowest during transfers Hypoxic pts are more likely to have a history of chest problems Hypoxia doubles mortality, but no longer significant if corrected for stroke severity No effect on long-term disability Rowat et al. Cerebrovasc Dis 2006;21:166-172. Selective high dose (45L/min) short burst oxygen supplementation National and international Stroke Guidelines Stroke Oxygen PILOT Study SOS PILOT Study – patient recruitment Recruitment Baseline Results Baseline Results Cont… Effect of oxygen supplementation on oxygen saturation Neurological Outcomeat 1 week Other results at 1 week Completeness of follow –up at 6 months How was the questionnaire completed? Outcomes at 6 months Conclusion 1 This pilot study demonstrates That routine oxygen supplementation effectively increased oxygen saturation when given in a non- intensive clinical environment That oxygen supplementation was well tolerated without observable adverse effects That the outcomes are feasible and deliver over 95% returns at 1 week (clinical) and 6 months (questionnaire) Conclusion 2 This pilot study was not powered to look at neurological or functional outcomes or to do subgroup analyses Results so far are that routine oxygen supplementation Led to a small but statistically significant improvement in neurological outcome at 1 week Had no significant effect on mortality and functional outcome at 6 months A larger study is required to determine whether routine oxygen supplementation is effective in reducing neurological deficit and improving functional outcome This queston was answered in 176 out of 231 returned questionnaires Baselin