Effects of milk salt supplementation on bone mineral gain in pubertal Chinese adolescents A 2-year randomized, double-blind, controlled, dose–response trial》.pdf

Bone 65 (2014) 69–76 Contents lists available at ScienceDirect Bone journal homepage: /locate/bone Original Full Length Article Effects of milk salt supplementation on bone mineral gain in pubertal Chinese adolescents: A 2-year randomized, double-blind, controlled, , ☆ ☆☆ dose–response trial Zhe-qing Zhang a, Xiao-ming Ma a, Zhen-wu Huang b, Xiao-guang Yang b, Yu-ming Chen a,⁎, Yi-xiang Su a,⁎⁎ a Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, Peoples Republic of China b Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, Peoples Republic of China a r t i c l e i n f o a b s t r a c t Article history: Background/objective: Adequate calcium intakes may enhance bone mineral accumulation during childhood. Received 27 February 2014 Little is known about the optimal calcium intake in Chinese adolescents. We examined the effects of three levels Revised 7 May 2014 of calcium intake on bone mineral accretion in adolescents. Accepted 9 May 2014 Methods: This was a 2-year randomized, double-blind, controlled trial. The subjects were randomly assigned to re- Available online 15 May 2014 ceive 40 g of milk powder containing 300 mg of calcium and 200 IU of vitamin D (Low-Ca group), or same milk