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Effects of FoxO1 on podocyte injury in diabetic rats》.pdf
Biochemical and Biophysical Research Communications 466 (2015) 260e266 Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: /locate/ybbrc Effects of FoxO1 on podocyte injury in diabetic rats a, b, 1 a, b, 1 a, b a, b a, b Feng Guo , Yuanyuan Zhang , Qingzhu Wang , Lei Ren , Yingni Zhou , Xiaojun Ma a, Lina Wu a, b, Guijun Qin a, * a Department of Endocrinology and Metabolism, The First Affi liated Hospital of Zhengzhou University, Zhengzhou 450052, China b Institute of Clinical Medicine, The First Affi liated Hospital of Zhengzhou University, Zhengzhou 450052, China a r t i c l e i n f o a b s t r a c t Article history: Objective: This study was designed to investigate the protective effect of forkhead transcription factor O1 Received 26 July 2015 (FoxO1) on podocyte injury in rats with diabetic nephropathy. Received in revised form Methods: Streptozotocin-induced diabetic rats were served as DM group, while DM rats transfected with 3 August 2015 blank lentiviral vectors (LV-pSC-GFP) or lentiviral vectors carrying constitutively active FoxO1 (LV-CA- Accepted 5 September 2015 FoxO1) were served as LV-NC group or LV-CA group, respectively. The control group (NG) consisted of Available online 7 September 2015 unin
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