DYRK1A overexpression decreases plasma lecithincholesterol acyltransferase activity and apolipoprotein A-I levels》.pdf

Molecular Genetics and Metabolism 110 (2013) 371–377 Contents lists available at ScienceDirect Molecular Genetics and Metabolism jour nal homepage: www.el sevie r. com/ locate/ ymgme DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels Asma Tlili a, Christophe Noll a, Sandrine Middendorp a, Arnaud Duchon b, Marie Jouan a, Eva Benabou a, Yann Hérault b, Jean-Louis Paul c,d, Jean-Maurice Delabar a, Nathalie Janel a,⁎ a Université Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology (BFA), EAC-CNRS 4413, Case 7104, 75205 Paris cedex 13, France b Institut de Génétique Biologie Moléculaire et Cellulaire, Translational Medicine and Neuroscience Program, IGBMC, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Institut Clinique de la Souris, ICS, 67404 Illkirch, France c AP-HP, Hôpital Européen Georges Pompidou, Service de Biochimie, 75015 Paris, France d Univ Paris-Sud, EA 4529, UFR de Pharmacie, 92296 Châtenay-Malabry, France a r t i c l e i n f o a b s t r a c t Article history: Background and aims: Down syndrome is caused by trisomy of all or part of human chromosome 21. Individuals Received 15 July 2013 with Down syndrome present some metabolic abnormalities involving lipoproteins, notably lower high-density Accepted 16 July 2013 lipoprotein levels associated with altered lecithin:cholesterol acyltransferase activity and apolipoprotein A-I Available online 20 July 2013 levels. DYRK1A is a kinase overexpressed in Down syndrome tha