A Novel Nanosystem to Enhance the Antitumor Activity of Lapatinib in Breast Cancer treatment Therapeutic. Efficacy Evaluation外文翻译.PDFVIP

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2015-09-30 发布于江西
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A Novel Nanosystem to Enhance the Antitumor Activity of Lapatinib in Breast Cancer treatment Therapeutic. Efficacy Evaluation外文翻译.PDF

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Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efﬁcacy evaluation Zhi-Jun Huo,1 Shi-Jiang Wang,2 Zhi-Qi Wang,3 Wen-Shu Zuo,1 Ping Liu,4 Bo Pang5 and Kai Liu6 1Departments of Breast Disease Center; 2Radiotherapy; 3Head and Neck Surgery, Shandong Cancer Hospital Institute, Shandong University, Jinan; 4 Department of Pharmacy, Shandong Provincial Hospital Afﬁliated to Shandong University, Shandong University, Jinan; 5Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan; 6Department of Gastrointestinal Surgery, Shandong Cancer Hospital Institute, Shandong University, Jinan, China Key words The present study was performed to investigate the therapeutic performance of apoptosis, breast cancer, drug delivery, hybrid nanoparti- polymer-lipid hybrid nanoparticles towards the delivery of lapatinib (LPT) in cles, lapatinib breast cancers. We have successfully developed the lapatinib-loaded polymer- Correspondence lipid hybrid nanosystem and showed its therapeutic potential in in vitro and Kai Liu, Department of Gastrointestinal Surgery, Shan- in vivo models of breast cancer. The nanoformulations consisted of a polymeric dong Cancer Hospital Institute, No. 440 Jiyan Road, core (poly[lactide-co-glycolide]-D-a-tocopheryl polyethylene glycol 1000 succinate Jinan 250117 China. [PLGA–TPGS]), which was then enveloped by a PEGylated lipid layer (DSPE-PEG) Tel: 0086-0531 Fax: 0086-0531 (PLPT) to maintain the structural integrity. The PLPT formulation controlled the E-mail: liuk45910@