Bell麻痹患者血清中疱疹类病毒及柯萨奇B组病毒IgM、IgG抗体检测分析.pdf

安徽医科大学学报990214 安徽医科大学学报 ACTA UNIVERSITATIS MEDICINALIS ANHUI 1999年 第34卷 第2期Vol.34 No.2 1999 Bell麻痹患者血清中疱疹类病毒及柯萨奇 B组病毒IgM、IgG抗体检测分析 林维芬　龚蕴贞　俞慕华　胡涛　杨兴涛　陈卫东 摘要　目的　探讨Bell麻痹与疱疹类病毒及柯萨奇B组病毒感染的关系。方法　采用间接ELISA法 检测Bell麻痹患者血清中水痘带状疱疹病毒(VZV)和单纯疱疹病毒Ⅰ型、Ⅱ型(HSV1，2)及柯萨 奇B组病毒1～6型(CB1～6)特异性IgM、IgG抗体的阳性率。结果　患者组血清抗体阳性率与对照 组相比：VZV-IgM、IgG阳性率差异有显著性(P0.01，P0.05)，HSV1-IgM、IgG阳性率差异有显 著(P0.05，P0.01)，HSV2-IgM阳性率差异有显著性(P0.05)，但HSV2-IgG阳性率差异无显著性 (P0.05)，在CB1～6-IgM、IgG阳性率检测中，除CB5-IgM差异有显著性(P0.05)外，其余型别两 组差异均无显著性(P0.05)。结论　Bell麻痹与VZV、HSV1感染有一定关系。 主题词　面神经麻痹/病毒学；疱疹病毒科；柯萨奇病毒B组 中图书资料分类法分类号　R745.12；R373 Detection of special IgM and IgG of VZY, HSV and coxsackievirus in the serums of Bell •s palsy patients Lin Weifen, Gong Yunzhen, Yu Muhua et al (Dept of Microbiology, Anhui Medical University, Hefei　230032) Abstract　Objective　To inquire into the relationship between Bell •s palsy and herpesvirus, coxsackievirus B infection. Methods　Indirect ELISA method was used to test and the sera of 38 Bell •s palsy patients were compared parallelly with 20 healthy persons •sera. Results　Through the comparison between positive rate of serum antibody of patient group and that of the normal, it is found that there was obvious difference between VZV-IgM(+), the IgM(+) rate and the normal (P0.01 ， P0.05); the divergence of HSV1-IgM(+), IgG(+) rate from the normal was marked too (P0.05 ， P0.01); the difference of HSV2-IgM(+) rate was also obvious (P0.05), while that of HSV2-IgG(+) was not notable (P0.05). In positive rate test of CB1～6-IgM,IgG, only CB5-IgM rate had obvious diversity(P0.05), while for other types two groups did not show distinct difference(P0.05). Conclusion　There is certain relationship between Bell •s palsy and VZV, HSV1 infection. MeSH　 fa