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The term “enzyme” was coined by Wilhelm Kuhne. 创造 crystallized 结晶 centrifugal supernatant 离心上清液 were used to imitate enzymes mesoporous介孔材料，多孔 DMF-2甲基甲酰胺 Polymer with enzyme-like activity 聚合物 noble-metal nanoclusters 贵金属纳米团簇 In the presence of dopamine在多巴胺的存在下 Molecularly imprinted polymers were invented by 分子印迹聚合物 Nano ceria as superoxide dismutase mimic. 纳米二氧化铈作为超氧化物歧化酶模拟。 peroxidase mimic. catalase,过氧化氢酶 Nano ceria as catalase and oxidase mimic纳米二氧化铈过氧化氢酶和氧化酶模拟 metal sulfide 硫化物 cobalt porphyrin钴 manganese锰 facile温和的 chemicals and reagents化学药品和试剂 syring注射器 thioacetamide 硫代乙酰胺 stretching vibration 伸缩振动峰 carbonyl group羰基 aromatic acid 芳香酸 calibration curve 校准线 have been extensively explored to mimic the structures and functions of natural enzymes through various approaches.and several monographs andnumerous excellent reviews have been published have been found to exhibit unexpected enzyme-like Although the progress and achievements of classic artificial enzymes have been thoroughly reviewed in the literature, no comprehensive review has been devoted to nanozymes we discuss the current challenges facing nanozyme technologies and future directions to realize their great potential. 新方法 Hybrid materials（杂化材料） formed by incorporating inorganicmaterials into a polymeric matrix have even more promisingadvantages, such as novel functionalities, enhanced biocompatibility and improved mechanical and chemical properties. Compared with natural enzymes and organic catalysts,the efficiency of most nanozymes are still lower. Therefore, the development of high performance nanozymes will be a hottopic for future research. Following these early works, we found that the pH-tunable oxidation ability of nanoceria to ferrocenecarboxylic acid (Fc-COOH).51 CeO2 nanoparticles, which exist in a mixed valence state (Ce3+, Ce4+), possess many unique proper