E质谱检测有机磷农药综述.pdf

Review Mass Spectrometric Analyses of Organophosphate Insecticide Oxon Protein Adducts Charles M. Thompson, John M. Prins, and Kathleen M. George Center for Structural and Functional Neuroscience, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA Jacobson 2006; Whyatt et al. 2004, 2005). Objective: Organophosphate (OP) insecticides continue to be used to control insect pests. Acute A neuropsychological assessment of children and chronic exposures to OP insecticides have been documented to cause adverse health effects, but exposed to OPs showed deficits in inhibitory few OP-adducted proteins have been correlated with these illnesses at the molecular level. Our aim motor control (Kofman et al. 2006). Two was to review the literature covering the current state of the art in mass spectrometry (MS) used to identify OP protein biomarkers. associated studies correlated developmental exposure with abnormal reflexes (Young et al. Data sOurces anD extractiOn: We identified general and specific research reports related to 2005) and mental developmental problems OP insecticides, OP toxicity, OP structure, and protein MS by searching PubMed and Chemical Abstracts for articles published before December 2008. (Eskenazi et al. 2007). OPs are thought to