以硅藻土固载的过氧乙酸为氧化剂的吡唑啉脱氢芳构化反应研究.pdfVIP

山西大学学报 (自然科学版)31(4)：556～560，2008 JournalofShanxiUniversity(Nat．Sci．Ed．) ArticleID：0253—2395(2008)04—0556-05 OxidativeAromatizationofPyrazolinesUsing Diatomite—SupportedPeraceticAcid LIu Jun—mei，WU Bu—lan (1．BeijingInstituteofPetrochemicalTechnology，Beijing102617，China； 2．SchoolofChemistryandChemicalEngineering，ShanxiUniversity，Taiyuan030006，China) Abstract：An effective synthetic method ofpyrazolesby dehydrogenati0n of corresponding pyrazolines was presentedandasimpleandavailableoxidationreagent，diatomite—supportedperaceticacidwasalsorecommended． Keywords：pyrazole；pyrazoline；diatomite—supported；peraceticacid；oxidativearomatization CLCnumber：TQ224．4；0612．6 Documentcode：A Thederivatives ofpyrazole are medicinally interesting compounds[ which possess anticonvusant，antiarhythmic， antiinflammatory，antipyretic，antidiatetic，antibacterial，tranquilizing，musclerelaxantand psychoanalepticactivities ．Many pyrazolederivativeshavebeenexploited aspharmaceuticalsand otherbioactivereagents．In thehumanbody，ithasbeen observedthatsomepyrazolinesareoxidizedtothecorrespondingpyrazoles．Therefore，amethodofobtainingpyrazolefrom relative pyrazoline by oxidative aromatization hasbeen developed biomimetically[ ”]．However．the aromatization of pyrazolinehasnotbeenfullystudied．andtheimprovementofyieldandreactiveconditionaredesiredurgently[ ． Tooxidizepyrazolinestocorrespondingpyrazoles，severaloxidants，suchasPd(OAc)2，MnO2，HgO，KMnO4，AgNOa，PdI2 (OAc)2andZn(NO3)2，havebeenemployed．But，thesereactionprocessesandoxidizingagentsfacesomeproblems，suchas lackingofenvironmentalfriendshipanddifficultytoisolatethefinalproducts．Thus，thereseem tobestillscopefordeveloping thenovelaromatizationreagentofpyrazolinesL ．Herein．to imitatetheoxido—reductionprocessesofperoxidatewith some nitrogen—co