3取代吲哚衍生物的合成_李记太.pdfVIP

19 5 化 学 进 展 Vol. 19 No.5 2007 5 PR GRESS IN CHEMISTRY May, 2007 3- 取代吲哚衍生物的合成* * * 李记太 代红光 蔺志平 ( 河北大学化学与环境科学学院河北省分析科学技术实验室 保定071002) 目前 哚化学的研究是杂环化学中最活跃的领域之 一, 特别是3-取代 哚衍生物, 已用于许多 天然产物和相应具有生物活性化合物重要骨架的构筑, 其合成方法的研究格外令人注目近年来, 由 哚一步 合成3-取代 哚衍生物的报道剧增本文按合成过程中所用催化剂的种类, 综述近几年来由 哚为原料一步 合成二 哚甲烷B- 哚酮B- 哚醇B- 哚硝基化合物和A- 哚甲胺等3-取代 哚衍生物的研究进展 哚 3-取代 哚 合成 : 626; 621.3 : A : 1005-281X(2007)05-0751-11 Synthesis of 3- Substituted Indole Derivatives * * Li Jitai Dai H ongguang L in Zhip ing (Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China) Abstract Theresearch of indoles has been oneof themost active areas of heterocyclic chemistry. In particular, 3- substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. Recently, there are a lot of reports on the synthesis of 3-substitutued indoles from indole. In this article, The one-pot synthesis of 3-substituted indole derivatives from indoles, such as bis(indolyl) methane, B-indolylketone, B-indolylalcohol, B-indolylnitro-compound, A-indolylmethylamine is reviewed according to the kinds of catalysts. Key words indole; 3-substituted indole; synthesis , 1 , [ 1] , ;3-,