DNA甲基化修饰对血管疾病稳态失衡的影响.pdfVIP

Hereditas (Beijing) 2015 年 3 月, 37(3): 221 ―232 综 述 DNA 甲基化修饰对血管疾病稳态失衡的影响 陈晓颖，叶华丹，洪青晓，周安楠，汤琳琳，段世伟 宁波大学医学院，浙江省病理生理学技术研究重点实验室，宁波 315211 摘要 : 自稳态平衡是机体生命活动的重要基础，在维持机体的正常生理功能中发挥重要作用。血管疾病中的稳 态失衡受物理、化学、生物等内外环境改变及致病因素的影响，其中氧稳态、血流稳态、糖脂代谢稳态在内环 境的影响中较为突出，由此引起的一系列表观遗传修饰将导致血管结构和功能的异常。表观遗传学中的DNA 甲基化与血管疾病的发生发展密不可分。此外，5-羟甲基胞嘧啶(5-hydroxymethylcytosine, 5hmC)及N6 - 甲基腺 嘌呤(N6 6 -methyladenine, m A)作为新的修饰碱基，将为表观遗传学研究提供新的思路。文章主要对DNA 甲基化 修饰变异在血管疾病稳态失衡方面的研究进展进行了阐述。 6 关键词 : DNA 甲基化; 血管稳态; 5hmC; m A The effects of DNA methylation on the homeostasis in vascular diseases Xiaoying Chen, Huadan Ye, Qingxiao Hong, Annan Zhou, Linlin Tang, Shiwei Duan Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China Abstract: Homeostasis is fundamental to maintain normal physiological functions in our body. Internal and external physical, chemical and biologial changes can cause dysregulation of vascular homeostasis, which is closely associated with the homeostasis of oxygen supply, blood transportation and lipid metabolism. Subsequent epigenetic modifications are able to lead to abnormal structures and function of vessels. DNA methylation has been shown to play a vital role in the develop- ment of vascular diseases. In addition, 5-hydroxymethylcytosine (5hmC) and N6 6 -methyladenine (m A), as new epigenetic modifications, provide additional clues for vascular diseases. In this review, we summarize the effects of DNA methylation on the homeostasis dysregulation in the vascular diseases. 6 Keywor