出凝血四项及总胆汁酸联合检测对肝病患者的意义.docVIP

出凝血四项及总胆汁酸联合检测对肝病患者的意义 【摘要】? 目的：分析出凝血四项及总胆汁酸随肝病患者的肝功能损害程度而变化的情况，并探讨联合检测出凝血四项及总胆汁酸的意义。方法：采用Beckman LX20 全自动生化分析仪对190例肝病患者及35例健康体检者的血清进行总胆汁酸（TBA）测定，同时用Coa DATA 4001半自动血凝仪测定血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）及纤维蛋白原（FIB）水平并做相关统计学分析。结果：TBA在各型肝病中与正常对照组比较均有统计学意义（P＜0.01），PT、APTT、TT、FIB四项在急性肝炎、慢性轻度病毒性肝炎患者中与正常对照组比较差异无显著性（P＞0.05），而在慢性中、重度肝炎、活动性肝硬化及重症肝病患者中与正常对照组比较差异有显著性（P＜0.01）。结论：联合检测PT、APTT、TT、FIB及TBA能较好地反映肝功能状况并评估肝脏受损程度，可以从多方面为肝病的临床诊断提供客观准确的实验依据。 【关键词】? 总胆汁酸；凝血酶原时间；活化部分凝血活酶时间；凝血酶时间；纤维蛋白原 　　The Significance of the Determining Jointly Four Items of the Natural Bleeding and Blood Coagulation and the Total Bile Acid in Hepatopathy Patients 　　LONG Zhengrong?　　The Central Hospital of Hengyang, Hengyang, Hu’nan 421001,China ??? Abstract：Objective To analyze the situation that four items of the natural bleeding and blood coagulation and the total bile acid (TBA) change with hepatopathy patients，extent of damage of liver function, and to explore the significance of the determining jointly four items of the natural bleeding and blood coagulation and the TBA.Methods Serum TBA levels were detected with Beckman LX20 in 190 cases of hepatopathy patient and 35 cases of health physical examination (the normal group) person, and Plasma PT,APTT,TT and the fibrinogen (FIB) levels were detected with Coa DATA 4001 semiautomatic coagulation detector, and the results of the different groups were analyzed by relevant statistics .Results The levels of TBA had significant difference between the hepatitis group and the normal group, P 0.01. The levels of PT, APTT, TT and FIB in the acute hepatitis, chronic slight hepatitis and the normal group have not a prominent difference (P 0.05), and those in the chronic mezzo hepatitis, serious hepatitis, hepatocirrhosis and heavy hepatic disease groups have much more prominent difference (P0.01) than the normal group.Conclusion To measure jointly PT, APTT, TT, FIB and TBA can give the liver function state and assess the extent of damage of liver well, ca