几种中药提取物和药物对乙醇脱氢酶活性影响的研究.pdfVIP

维普资讯 进作用 ．中国临床药理学与治疗学，2002，7(5)：434— [7]蒋新国，崔景斌 ，方晓玲，等．药物的鼻黏膜纤毛毒性及 436． 评价方法 ．药学学报，1995，30(11)：848—853． [5]许碧莲，王晖，许卫铭 ．冰片对川芎嗪促透作用的研 [8]许庚，卜国铉，董廷，等．十二种药物对蛙 口腔粘膜纤毛 究．中成药，2001，23(12)：864—867． 活性的影响．中华耳鼻咽喉科杂志，1989，24(1)：24· [6]GizurarsonS，ChristopherM，MartinG．P，eta1．Thein- 25． fluenceofinsulinandsomeexcipientsusedinnasalinsulin [9]潘嘉 ．川芎嗪及冰片对蛙黏膜纤毛转运能力的影响． preparationsonmucociliaryclearnace．IntJPharm，1990， 中草药，2004，35(1)：1282—1284． 65：243．247． (2005—10—24收稿 ) EffectofLigustrazine，SyntheticBorneolon LastingTimeofCiliaryM ovement PANJia，ZOUWen-jun，LIUJie，ZHANGBai-jia，LIUYa—OU，PANXiao-juan (DepartmentofPharmacology，SicuanInstituteofChineseMaterialMedica，Chengdu610041，China) Abstract Objective：Tostudytheusingofthemethodinvitroandinvivooflastingtimeofciliarymovementinligustrazine，syn- theticborneo1．Methods：(1)Methodinvitro-Thelastingtimeofciliarymovementwasobservedwithforty—foldopticalmicroscopeafter droppingliquidmedicineonexteacorporealfrogpalatemucos~ Thenmucosawascleared．Itwasobservedwhethertheciliarymove- mentwasrecoverednadthelastingtimewasrecordedfromrecoveringtostoppingonceagain．(2)Methodinvivo—Liquidmedicineor nomr alsalinewasdroppedonfrogpalatemucosabycontactingthirtyminutes．Thenmucosawascleared．Thelastingtimeofciliary movementwasobservedwithforty—foldopticalmicroscopebysepraatingpalatemucos~ Results：Relativelypercentageoflastingtimeof ciliarymovementofligustrazineinvitronadinvivowas9．8％ 、87．3％ ；Therelativelypercentageofsyntheticborneolinvitroandinvi- VOwas9．3％ 、89．5％．Conclusion：Themethodinvitroandinvivooflastingtimeofciliary movementcanbetheoneoftheselecting waysofChinesedrug’Stoxicityofnasalmucosa，andithav