SD大鼠实验性坐骨神经损伤的运动神经传导检测.pdfVIP

2010 06 1806 7 SD 1 2 申小年 倪家骧 [ ] :观察SD 大鼠不同坐骨神经损伤所致的运动神经传导功能: 30 只大鼠随机分 3 ( 10 只/ ) : 坐骨 神经完全切断再植 ( CCRI) ; 慢性嵌压性神经损伤 ( CCI) ; 坐骨神经分支选择结扎切断 ( SNI) 分别于术后10d 和 30d 用肌电图仪电刺激大鼠的坐骨神经远近端, 在腓肠肌肌腹部记录复合肌肉动作电位, 计算出坐骨神经的运动传导速 度( MCV) 并与健侧( 左侧) 作对照: 大鼠损伤侧的运动神经传导波形离散波幅减低, 表现为神经传导阻滞: 神经传导检测对于大鼠坐骨神经不同部位不同程度损伤的诊断治疗效果和预后评估有应用价值 [ ] 神经再植( CRI) ; 慢性嵌压性神经损伤( CCI) ; 坐骨神经分支选择结扎切断( SNI) ; 运动神经传导速度( M NCV) + [ ] R745. 4 2 [ ] A [ ]2010) The Detection of Motor Nerve Conduction in Rats with Injury of Sciatic Nerve SH EN X i aoni an 1 N I J i ax iang 1 1Ort opedics and Traumatology Speciality , Department of Medicine, An ui College of Traditional C inese Medicine, An ui 24 1000, C ina 2 Department of Pain Medicine, Xuanwu H ospital, Capital University of Medical Sciences Abstract Objective: To detect t e motor nerve conduction velocity ( MCV) of t e Sprague- Daw ley rats w it injury of sci at ic nerve by different w ays. Methods: T irt y ealt y adult SD rats were randomly divided into t e sciatic nerve completely cutting and reimplantation group ( CCRI) , c ronical constriction injury ( CCI) and spared nerve injury group ( SNI) . Com pound muscle action potential were performed to t e distal and proximal sciatic nerve trunks and calculated at gastrocnemius muscle belly 10 and 30 days aft er t e operation, and t en compared w it t e normal cont rol. Results:MCV on t e on t e in jured sciatic nerves was discrete and amplit ude was degrade, s ow ing conduction blockage. Conclusion: It is meaningful to perform MCV detect ion as for t e diagnosis, t erapy and prognosis of sc