小胶质细胞作为防治阿尔茨海默病的新靶标和相关药物研究进展副本.pdfVIP

军事医学科学院院刊 2009 年 8月 第 33卷 第 4 期 388 Bu llA cad M ilM ed Sci, Aug 2009; Vol 33 N o 4 * 刘 港, 杨 胜, 周文霞 , 张永祥 ( 军事医学科学院毒物药物研究所, 北京 100850) [] 。( A lzh emi erc s d isease, AD) , B2( B2am y loid, AB ) , AB, , , AD。 AD , , , AB AD, 。 [] ; ; B2; [ ] R 741 [] A [] 100025501( 2009) 0420388204 Advances in r esearch on m icroglia as a pharm acological target in pr evention and treatm ent of Alzhemi er c s disease * LI U Gang, YANG Sh eng, ZHOU Wen 2X ia , ZHAN G Yong 2X iang ( In stitu te of P ha rmacology and Toxicology, A cadem y ofM ilitaryM ed ica l Sc ien ces, Be i ing 100850, Ch in a) [Abstract] M ic roglia, th e resident m acroph ages in th e centra l n ervou s system, can b e activa ted by B2amy loid prote in ( AB), th e m a or com p on en t of sen ile p laques in A lzhe mi ercs d isease( AD). A ctivated m icroglia not on ly e lmi in ate AB but a lso re lease in flamma tory factors, wh ich p lay a cr itica l role in AD p athology. R ecent report s strongly suggest th at regu la ting m icroglia fun ction b e a prom ising th erapeutic approach toAD. In th is p ap er the research advances in m icroglia as a pharma2 cological targe t in th e prevention and trea mt en t of AD is rev iewed. [K ey words] m icroglia; A lzh e mi ercs d isease; B2am y loid prote in; dru g th erapy 阿尔茨海默病 ( A lzh emi erc s disease, AD )是发生在老年 内, 小胶质细胞具有清除死亡细胞碎片和吞噬、清除、降解 期或老年前期的一种慢性退化性疾病, 以进行性记忆减退、 AB沉积的功能。AB 沉积部位的小胶质细胞内含有 AB 纤 认知障碍、人格改变为主要特征。B2淀粉样蛋白( B2amy loid, 维, 经在体与离体实验证实, 该 AB 纤维是通过小胶质细胞 AB )沉积形成的老年斑是其脑内的主要病理学特征之一。