内科学 淋巴瘤-邹善华【荐】.ppt

LymphomaZhongshan Hospital ,Fudan UniversityZou Shanhua General Considerations Definition：A group of neoplastic diseases of lymphoid tissues Classification： Hodgkin′s Disease, HD (Hodgkin′s Lymphoma) Non Hodgkin ′s Lymphoma,NHL) General Considerations Clinical Features： Painless, progressive lymphadenectasis Fever, weight loss, night sweat；cachexia Hepatosplenomegaly Epidemiology： Incidence： in cities / in the country; male/female; age HD 8～11％；NHL 90% Etiology and Pathogenesis Virulogy: EB virus→Burkitt lymphoma, HD Human T-cell Lymphotropic Virus type 1, HTLV-1→ Adult T-cell lymphoma/leukemia , ATL HTLV-2→Mycosis Fungoides Helicobacter Pylori→MALT lymphoma Kaposi sarcoma-associated herpesvirus →primary body cavity lymphoma Etiology and Pathogenesis Immune States of Host： Immunodeficiency/immunosuppression Mechanism：Antigenic stimulation → lymphadenosis ( modulation↓) → infinite proliferation →lymphoma Classification of Lymphoma HD：Reed-Sternberg(R-S) Cell Classification of Lymphoma Rye Classification ，1966 Lymphocyte predominance Nodular sclerosis Mixed cellularity Lymphocyte depletion Classification of Lymphoma WHO Classification, 2001 Nodular lymphocyte predominance Hodgkins lymphoma Classical Hodgkins lymphoma Lymphocyte-rich classical Hodgkins lymphoma Nodular sclerosis Hodgkins lymphoma Mixed cellularity Hodgkins lymphoma Lymphocyte depletion Hodgkins lymphoma Classification of Lymphoma NHL： Classification of Lymphoma NHL： IWF，1982 REAL，1994 WHO，2001 Working Formulation Low-grade l