Toll样受体7介导的抗病毒天然免疫反应研究进展.pdfVIP

2010,40(06) :645649 Chinese Veterinary Science : S 852. 42 : A : 2010 Toll 7 1 1 1 1 1 1* 2* 何小兵, 房永祥 , 贾怀杰 , 陈国华 , 曾 爽, 景志忠 ,程国锋 ( 1. , 730046;2. , 200241) : 概述了T oll 样受体( TLRs) 的发现种类及 作用模式,重点介绍了T LR7 的分子结构组织分 布识别的配体以及依赖MyD88 接头分子的信号转导通路, 最后, 综述了TLR7 介导的抗病毒效应的研究 进展提出, 对T LR7 及 作用机制的研究必将有助于新型动物用疫苗的创制 : Toll 样受体7;单链RNA;髓样分化因子88; 抗病毒免疫 Advance in tolllike receptor 7mediated antiviral innate immune responses 1 1 1 1 1 HE iaobing ,FANG Yongxiang ,JIA Huaijie , CHEN Guohua ,ZENG Shuang , 1 2 JING Zhizhong , CHENG Guofeng ( 1. K ey L abor atory of Veter inary Parasitology of Gansu Pr ov ince/ K ey L aboratory of Veter inary P ublic H ealth of the M inisitry of A g r iculture/ S tate K ey L abor atory of Veter inary Etiolog ical B iology/ L an hou Veter inary Resear ch I nstitute , Chinese A cademy of A g r icul tur al Sciences , Lan hou 730046, China; 2. K ey L abo ratory of Veter inary P ar as itology of the M inistry of A g r icultur e/ S hang hai Veter inary Resear ch I nstitute, Chinese A cademy of A g r icultur al S ciences, S hang hai 200241, China) Abstract: T he discovery of TLRs,function patterns and sorts were summarized. The review is focused on the molecular structure, tissue distribution, recognized ligands and signaling pathways dependent on MyD88 of T LR7. Finally the advance in TLR7mediated antiviral immune responses was discussed. It is believed on that T LR7 could help develope new vaccines for animals. Key words: T LR7;ssRNA;MyD88;antiviral immunity , ,