循证评价与遴选中国东中西部乡院基本药物系列之二：评价标准、方法与流程研究.pdfVIP

• 论  著  方法学研究 2012, 12(3): 347 356 中国循证医学杂志 ～ 循证评价与遴选中国东中西部乡院基本药物 系列之二：评价标准、方法与流程研究 * 李鸿浩  李幼平  王  莉  杨晓妍 四川大学华西医院中国循证医学中心（成都 610041 ） 摘要  目的  制定满足我国8 个示范乡院需求的循证评价与遴选基本药物的标准、方法和流程。方法 描 述性分析比较WHO 基本药物评价与遴选和GRADE 证据质量与推荐强度的标准、方法、流程的异同和利 弊，结合本系列前期研究结果优化组合并改进我国示范乡院基本药物的循证评价与遴选标准、方法及流程。用 GRADEprofiler 等软件评价证据质量。结果 ①初步制定出本土化的乡院基本药物循证评价与遴选标准、方法、 流程，并确定评价工具。②初步确立了标准化、系统化、透明化疾病名、药品名、指南与检索等。结论 ①本研究 初步制定出评价与遴选我国示范乡院基本药物时比较有效性、安全性、成本– 效果及适用性的最佳证据检索、评 价与推荐标准、方法和流程；②根据“有证查证用证、无证创证用证”原则，对乡院循证评价与遴选基本药物的标 准、方法与流程的本土化、规范化和透明化作了有益探索。 关键词  乡镇卫生院；基本药物；循证评价与遴选；评价标准与方法；GRADE Evidence-Based Evaluation and Selection of Essential Medicine for Pilot Township Health Centers Located in Eastern, Central and Western China, Part II: Study on Evaluation Standards, Methods and Processes * LI Hong-hao, LI You-ping , WANG Li, YANG Xiao-yan Chinese Evidence-Based Medicine Center, West China Hospital, Chengdu 610041, China Abstract Objective To establish standards, methods and processes for evidence-based evaluation and selection of essential medicine that meet the needs of the 8 pilot township health centers in China. Methods A descriptive analysis was conducted to compare the similarities/differences and the advantages/disadvantages of the standards, methods and processes between the World Health Organization (WHO) essential medicines evaluation and selection, and the GRADE evidence quality and recommend intensity. In combination with the former outcomes of this series of study, the standards, methods and processes of evidence-based evaluation and selection of essential medicines in the domestic pilot township health centers were optimized, restructured and improved. Softwares such as GRADEprofiler were used to assess the qual- ity of evidence. Results a) Localized standards,