一个新的细胞死亡形式- Parthanatos.pdfVIP

HEREDITAS (Beijing) 2010 9 , 32(9): 881―885 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2010.00881 一个新的细胞死亡形式: Parthanatos 王连邦, 张丽英, 单春华 , 150040 Parthanatos 是发生在中风、帕金森氏病、心力衰竭、糖尿病以及缺血再灌注损伤等疾病中的一种细胞死 亡。该死亡是由兴奋性中毒引起的DNA 损伤, 进一步导致PARP-1 激活而引发的细胞死亡, 又称为PARP-1 依 赖性细胞死亡。目前关于Parthanatos 的研究还处于初期阶段, 对其信号通路的分子机制说法还不统一。文章就 Parthanatos 分子机制的研究进展进行了综述。 Parthanatos; 多聚ADP 核糖聚合酶-1; 多聚ADP 核糖; 凋亡诱导因子; 细胞死亡 A new form of cell death: Parthanatos WANG Lian-Bang, ZHANG Li-Ying, SHAN Chun-Hua Laboratory of Development Biology , College of Life Science, Northeast Forestry University , Harbin 150040, China Abstract: Parthanatos is a form of cell death, which often occurs in many diseases such as stroke, Parkinson’s disease, heart attack, diabetes, and ischemia reperfusion injury. In a cell, the activation of PARP-1 caused by excitotoxicity leads to Parthanatos, which is also known as PARP-1-dependent cell death. There are multiple cell signaling pathways involved in the process of Parthanatos, which have not been fully understood. The main focus of this article is underlying molecular mechanisms of Parthanatos. Keywords: Parthanatos; PARP-1; PAR; AIF; cell death ADP -1(Poly Caspase (ADP-ribose) polymerase-1, PARP-1), [3] , Harraz [1] Parthanatos PARP-1 (thanatos: , [5] , ) Parthanatos Parthanatos Parthanatos DNA ; , PARP-1 , Parthanatos [2]; PAR , Parthanatos (Apoptosis-inducing factor, AIF) [6,7]; (Necroptosis) , Par- NAD ATP thanatos ,