D二聚体与原发性肾病综合征临床及病理的相关分析.docVIP

D二聚体与原发性肾病综合征临床及病理的相关分析 项新，施燕春，何坤，黄典胜，黄振华，李洁，陆玲娜，冯振伟 （广西民族医院 肾内科，广西 南宁 530001） 摘要：【目的】对D二聚体与原发性肾病综合征临床及病理资料相关性进行分析，D—Dimer with clinical and pathological data in Patients with primary nephrotic syndrome XIANG Xin, SHI Yan Chun,LU Ling Na,HE Kun，HUANG Dian Sheng，LI Jie，HUANG Zhen Hua，FENG Zhen Wei (GUANG XI MIN ZU HOSPITAL Department of Nephrology，Nan Ning,Guang Xi,530001,China) Abstract:[Objective] To investigate the relationship of serum CRP with clinical and pathological data in Patients with primary nephrotic syndrome.To ensure its clinical significance.[Methods] to obtain general clinic information,such as blood fat,renal function，and renal pathology and so on.[Result] ①Compared with normal controls，the level of serum CRP was significantly increased（ P0.05）.②There is a positive correlation between the level of serum CRP and 24h urine protein, No correlation was found in the the level of serum CRP with ALB, BUN，Scr，CHOL and TG level,P0.05.③The level of CRP was higher in pations with Minimalchangenephropathy than membranous nephropathy or Focal segmental glomerulonephritis,(P0.05).No correlation was found in the level of crp with other groups of renal pathology,P0.05.[conclusion] Primary nephrotic syndrome has hypercoagulable state, D—Dimer can reflect the degree of proteinuria and renal damage, and may be indirectly predicted nephrotic syndrome and pathological types. Key words: D—Dimer；nephrotic syndrome; relationship 原发性肾病综合征（PNS）是一类以炎症反应为主的自身免疫性疾病，是严重危害人类健康的一组常见的肾脏疾病，PNS患者存在不同程度的血液高凝状态, 易于形成血栓, 血浆D二聚体(D—Dimer，简称DD)对本院自200年1月至 20年月期间来收治的例，PNS的诊断标准：1) 24h尿蛋白＞3.5g/d；2) 血清白蛋白＜30g/L。排除标准：1) 继发性NS患者；2) 并发感染，包括全身或局部的细菌、真菌、支原体等感染；3) 存在组织或器官损伤，包括近期有创伤、烧伤、手术、心肌梗死等病史；4) 恶性肿瘤患者，包括各种实体瘤和血液病；5)自身免疫性疾病患者，如类风湿性关节炎、系统性红斑狼疮等；6) 输注血浆或白蛋白等影响血清白蛋白浓度者。年龄(36.7±17.7)岁，全部病例均行肾穿刺活检，并且在入院前2Wk内未应用激素类药物，共120例，男68女52例，年龄最小16岁，最大70岁，平均年龄38.7±13.00岁。对照组，60例选自本院健康体检者，男36例，女24例，年龄最小19岁，最大65岁，平均年龄43.03±13.84岁。对照组与PNS组间年龄、性别比较无显著性差异(pO.05)有可比性。且血、尿常规和肝肾功能正常,无原发、继发性肾小球疾病及肿瘤等其他疾病。 1.2 收集患者病