有哪些信誉好的足球投注网站文献_Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids.pdfVIP
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Review Article Page 1 of 10 Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine? 1,2,3,4 1,2,3,4 1,2,3,4 2 2 Marius Ilie *, Véronique Hofman *, Elodie Long , Olivier Bordone , Eric Selva , Kevin Washetine2, Charles Hugo Marquette1,5, Paul Hofman1,2,3,4 1INSERM U1081/CNRS UMR7284, Team 3, University of Nice Sophia Antipolis, Antoine Lacassagne Cancer Center, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France; 2Human Biobank, 3Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France; 4Cancer Research Association (ARC) Labelled Team, Villejuif, France; 5Department of Pneumology, Pasteur Hospital, Nice, France *These authors contributed equally to this work. Correspondence to: Paul Hofman, MD, PhD. Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, 30 avenue de la voie romaine, 06001 Nice Cedex 01, France. Email: hofman.p@chu-nice.fr. Abstract: The practice of “liquid biopsy” as a diagnostic, prognostic and theranostic tool in non-small cell lung cancer (NSCLC) patients is an appealing approach, at least in theory, since it is noninvasive and easily repeated. In particular, this approach allows patient monitoring during treatment, as well as the detection of different genomic alterations that are potentially accessible to targeted therapy or are associated with treatment resistance. However, clinical routine practice is slow to adopt th
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